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Insulin Resistance, Ceramide Accumulation, and Endoplasmic Reticulum Stress in Human Chronic Alcohol-Related Liver Disease

Background. Chronic alcohol-related liver disease (ALD) is mediated by insulin resistance, mitochondrial dysfunction, inflammation, oxidative stress, and DNA damage. Recent studies suggest that dysregulated lipid metabolism with accumulation of ceramides, together with ER stress potentiate hepatic i...

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Detalles Bibliográficos
Autores principales:	Longato, Lisa, Ripp, Kelsey, Setshedi, Mashiko, Dostalek, Miroslav, Akhlaghi, Fatemeh, Branda, Mark, Wands, Jack R., de la Monte, Suzanne M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347750/ https://www.ncbi.nlm.nih.gov/pubmed/22577490 http://dx.doi.org/10.1155/2012/479348

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