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Ejection Fraction and Mortality Rate of Patients with Isolated Acute Inferior Myocardial Infarction Reperfused by Streptokinase
BACKGROUND: This study aimed to evaluate the effects of streptokinase on left ventricular ejection fraction and mortality rate of patients with inferior acute myocardial infarction (AMI) without right ventricular myocardial infarction (RVMI). METHODS: Fifty five consecutive patients with the diagnos...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347851/ https://www.ncbi.nlm.nih.gov/pubmed/22577446 |
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author | Beiraghdar, Mozhdeh Pourmoghaddas, Zahra Reza Torknezhad, Mohammad Torkan, Ali |
author_facet | Beiraghdar, Mozhdeh Pourmoghaddas, Zahra Reza Torknezhad, Mohammad Torkan, Ali |
author_sort | Beiraghdar, Mozhdeh |
collection | PubMed |
description | BACKGROUND: This study aimed to evaluate the effects of streptokinase on left ventricular ejection fraction and mortality rate of patients with inferior acute myocardial infarction (AMI) without right ventricular myocardial infarction (RVMI). METHODS: Fifty five consecutive patients with the diagnosis of inferior AMI without RVMI in the coronary care unit (CCU) of Shariati Hospital in Isfahan were selected for this study. Patients who had a history and/or electrocardiogram (ECG) evidence of previous myocardial infarction, evidence of bundle branch block, historical or clinical findings of valvular or other non-coronary heart diseases or heart failure were excluded. Participants were divided into two groups. Group one (n=28) had no contraindication for taking thrombolytic therapy and group two (n=27) had at least one contraindication for this treatment. Patients in group one took 1,000,000 units streptokinase for one hour. Three days later, LVEF of all participants was measured by an experienced cardiologist using 2-dimentiona1 echocardiography. Patients were followed up until four weeks to assess the mortality rate. RESULTS: One death in the first 24 hours was reported in group one. However, no death was reported in any group until four weeks after discharge. There was no significant difference in mortality rate during the first 24 hours and four weeks after discharge between the two groups. Mean LVEF in the two groups did not show any significant difference (P=0.21). CONCLUSION: Probably streptokinase has no effects on one-month mortality rate and LVEF in patients with inferior AMI without RVMI. Therefore, streptokinase side effects must be taken into consideration when being administered for this group of patients. |
format | Online Article Text |
id | pubmed-3347851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-33478512012-05-10 Ejection Fraction and Mortality Rate of Patients with Isolated Acute Inferior Myocardial Infarction Reperfused by Streptokinase Beiraghdar, Mozhdeh Pourmoghaddas, Zahra Reza Torknezhad, Mohammad Torkan, Ali ARYA Atheroscler Original Article BACKGROUND: This study aimed to evaluate the effects of streptokinase on left ventricular ejection fraction and mortality rate of patients with inferior acute myocardial infarction (AMI) without right ventricular myocardial infarction (RVMI). METHODS: Fifty five consecutive patients with the diagnosis of inferior AMI without RVMI in the coronary care unit (CCU) of Shariati Hospital in Isfahan were selected for this study. Patients who had a history and/or electrocardiogram (ECG) evidence of previous myocardial infarction, evidence of bundle branch block, historical or clinical findings of valvular or other non-coronary heart diseases or heart failure were excluded. Participants were divided into two groups. Group one (n=28) had no contraindication for taking thrombolytic therapy and group two (n=27) had at least one contraindication for this treatment. Patients in group one took 1,000,000 units streptokinase for one hour. Three days later, LVEF of all participants was measured by an experienced cardiologist using 2-dimentiona1 echocardiography. Patients were followed up until four weeks to assess the mortality rate. RESULTS: One death in the first 24 hours was reported in group one. However, no death was reported in any group until four weeks after discharge. There was no significant difference in mortality rate during the first 24 hours and four weeks after discharge between the two groups. Mean LVEF in the two groups did not show any significant difference (P=0.21). CONCLUSION: Probably streptokinase has no effects on one-month mortality rate and LVEF in patients with inferior AMI without RVMI. Therefore, streptokinase side effects must be taken into consideration when being administered for this group of patients. Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences 2011 /pmc/articles/PMC3347851/ /pubmed/22577446 Text en © 2011 Isfahan Cardiovascular Research Center & Isfahan University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Beiraghdar, Mozhdeh Pourmoghaddas, Zahra Reza Torknezhad, Mohammad Torkan, Ali Ejection Fraction and Mortality Rate of Patients with Isolated Acute Inferior Myocardial Infarction Reperfused by Streptokinase |
title | Ejection Fraction and Mortality Rate of Patients with Isolated Acute Inferior Myocardial Infarction Reperfused by Streptokinase |
title_full | Ejection Fraction and Mortality Rate of Patients with Isolated Acute Inferior Myocardial Infarction Reperfused by Streptokinase |
title_fullStr | Ejection Fraction and Mortality Rate of Patients with Isolated Acute Inferior Myocardial Infarction Reperfused by Streptokinase |
title_full_unstemmed | Ejection Fraction and Mortality Rate of Patients with Isolated Acute Inferior Myocardial Infarction Reperfused by Streptokinase |
title_short | Ejection Fraction and Mortality Rate of Patients with Isolated Acute Inferior Myocardial Infarction Reperfused by Streptokinase |
title_sort | ejection fraction and mortality rate of patients with isolated acute inferior myocardial infarction reperfused by streptokinase |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347851/ https://www.ncbi.nlm.nih.gov/pubmed/22577446 |
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