Cargando…

Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease

BACKGOUND: No disease modifying treatment currently exists for Huntington's disease (HD), a fatal neurodegenerative disorder characterized by the formation of amyloid-like aggregates of the mutated huntingtin protein. Curcumin is a naturally occurring polyphenolic compound with Congo red-like a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hickey, Miriam A, Zhu, Chunni, Medvedeva, Vera, Lerner, Renata P, Patassini, Stefano, Franich, Nicholas R, Maiti, Panchanan, Frautschy, Sally A, Zeitlin, Scott, Levine, Michael S, Chesselet, Marie-Françoise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348060/ https://www.ncbi.nlm.nih.gov/pubmed/22475209 http://dx.doi.org/10.1186/1750-1326-7-12

Ejemplares similares

Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene
por: Franich, Nicholas R., et al.
Publicado: (2019)

Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin
por: Maiti, Panchanan, et al.
Publicado: (2014)

Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington’s Disease Knock-In Mice
por: Neto, João Luís, et al.
Publicado: (2017)

Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out
por: Loupe, Jacob M, et al.
Publicado: (2020)

Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice
por: Reidling, Jack C., et al.
Publicado: (2017)

Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington’s Disease Knock-In Mouse Models
por: Franich, Nicholas R., et al.
Publicado: (2018)

A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal huntingtin’s polyglutamine stretch on CAG140 mouse model pathogenesis
por: Zheng, Shuqiu, et al.
Publicado: (2012)

Comparative Neuroprotective Effects of Dietary Curcumin and Solid Lipid Curcumin Particles in Cultured Mouse Neuroblastoma Cells after Exposure to Aβ42
por: Maiti, Panchanan, et al.
Publicado: (2017)

Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease
por: Maiti, Panchanan, et al.
Publicado: (2018)

Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases
por: Maiti, Panchanan, et al.
Publicado: (2018)

Msh2 Acts in Medium-Spiny Striatal Neurons as an Enhancer of CAG Instability and Mutant Huntingtin Phenotypes in Huntington’s Disease Knock-In Mice
por: Kovalenko, Marina, et al.
Publicado: (2012)

A Broad Phenotypic Screen Identifies Novel Phenotypes Driven by a Single Mutant Allele in Huntington’s Disease CAG Knock-In Mice
por: Hölter, Sabine M., et al.
Publicado: (2013)

Evaluation of Histone Deacetylases as Drug Targets in Huntington’s Disease models: Study of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model.
por: Quinti, Luisa, et al.
Publicado: (2010)

Retraction Note: Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease
por: Maiti, Panchanan, et al.
Publicado: (2023)

Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington’s Disease
por: Peng, Qi, et al.
Publicado: (2016)

Solid Lipid Curcumin Particles Induce More DNA Fragmentation and Cell Death in Cultured Human Glioblastoma Cells than Does Natural Curcumin
por: Maiti, Panchanan, et al.
Publicado: (2017)

Intermediate CAG Repeats in Huntington's Disease: Analysis of COHORT
por: Ha, Ainhi D., et al.
Publicado: (2012)

What is the Pathogenic CAG Expansion Length in Huntington’s Disease?
por: Donaldson, Jasmine, et al.
Publicado: (2021)

Role of cerebral cortex in the neuropathology of Huntington's disease
por: Estrada-Sánchez, Ana M., et al.
Publicado: (2013)

Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice
por: McClory, Hollis, et al.
Publicado: (2014)

Induced Pluripotent Stem Cell-Derived Neural Stem Cell Transplantations Reduced Behavioral Deficits and Ameliorated Neuropathological Changes in YAC128 Mouse Model of Huntington's Disease
por: Al-Gharaibeh, Abeer, et al.
Publicado: (2017)

CRISPR-Cas9 Mediated Gene-Silencing of the Mutant Huntingtin Gene in an In Vitro Model of Huntington’s Disease
por: Kolli, Nivya, et al.
Publicado: (2017)

Curcumin and Solid Lipid Curcumin Particles Induce Autophagy, but Inhibit Mitophagy and the PI3K-Akt/mTOR Pathway in Cultured Glioblastoma Cells
por: Maiti, Panchanan, et al.
Publicado: (2019)

Solid Lipid Curcumin Particles Protect Medium Spiny Neuronal Morphology, and Reduce Learning and Memory Deficits in the YAC128 Mouse Model of Huntington’s Disease
por: Gharaibeh, Abeer, et al.
Publicado: (2020)

Late-onset Huntington’s disease with 40–42 CAG expansion
por: Capiluppi, Elisa, et al.
Publicado: (2019)

Differential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease
por: Deng, Yun-Ping, et al.
Publicado: (2014)

CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset
Publicado: (2019)

Reduction of Huntington’s Disease RNA Foci by CAG Repeat-Targeting Reagents
por: Urbanek, Martyna O., et al.
Publicado: (2017)

Parkinsonism with a Hint of Huntington’s from 29 CAG Repeats in HTT
por: JOT, Sipilä
Publicado: (2019)

Case report and literature review of Huntington disease with intermediate CAG expansion
por: Jevtic, Stefan D, et al.
Publicado: (2020)

Silencing of the Mutant Huntingtin Gene through CRISPR-Cas9 Improves the Mitochondrial Biomarkers in an In Vitro Model of Huntington’s Disease
por: Dunbar, Gary L., et al.
Publicado: (2019)

Quantification of Age-Dependent Somatic CAG Repeat Instability in Hdh CAG Knock-In Mice Reveals Different Expansion Dynamics in Striatum and Liver
por: Lee, Jong-Min, et al.
Publicado: (2011)

Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments
por: Maiti, Panchanan, et al.
Publicado: (2019)

Huntington’s disease mouse models: unraveling the pathology caused by CAG repeat expansion
por: Kaye, Julia, et al.
Publicado: (2021)

Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse
por: Benskey, Matthew J., et al.
Publicado: (2023)

Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice
por: Virlogeux, Amandine, et al.
Publicado: (2021)

PAK in Alzheimer disease, Huntington disease and X-linked mental retardation
por: Ma, Qiu-Lan, et al.
Publicado: (2012)

Continuous and Periodic Expansion of CAG Repeats in Huntington's Disease R6/1 Mice
por: Møllersen, Linda, et al.
Publicado: (2010)

CAG-Expansion Haplotype Analysis in a Population with a Low Prevalence of Huntington's Disease
por: Pulkes, Teeratorn, et al.
Publicado: (2014)

Problems and solutions for the analysis of somatic CAG repeat expansion and their relationship to Huntington's disease toxicity
por: Budworth, Helen, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nmnrusu4n0eahfvaj03isa3ten