Dll4–Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice

Delta-like ligand 4 (Dll4)–Notch signaling is essential for T cell development and alternative thymic lineage decisions. How Dll4–Notch signaling affects pro-T cell fate and thymic dendritic cell (tDC) development is unknown. We found that Dll4 pharmacological blockade induces accumulation of tDCs a...

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Detalles Bibliográficos
Autores principales: Billiard, Fabienne, Lobry, Camille, Darrasse-Jèze, Guillaume, Waite, Janelle, Liu, Xia, Mouquet, Hugo, DaNave, Amanda, Tait, Michelle, Idoyaga, Juliana, Leboeuf, Marylène, Kyratsous, Christos A., Burton, Jacquelynn, Kalter, Julie, Klinakis, Apostolos, Zhang, Wen, Thurston, Gavin, Merad, Miriam, Steinman, Ralph M., Murphy, Andrew J., Yancopoulos, George D., Aifantis, Iannis, Skokos, Dimitris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348095/
https://www.ncbi.nlm.nih.gov/pubmed/22547652
http://dx.doi.org/10.1084/jem.20111615

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