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Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase

Immunoglobulin (Ig) affinity maturation requires the enzyme AID, which converts cytosines (C) in Ig genes into uracils (U). This alone produces C:G to T:A transition mutations. Processing of U:G base pairs via U N-glycosylase 2 (UNG2) or MutSα generates further point mutations, predominantly at G:C...

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Detalles Bibliográficos
Autores principales:	Sharbeen, George, Yee, Christine W.Y., Smith, Adrian L., Jolly, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348097/ https://www.ncbi.nlm.nih.gov/pubmed/22529268 http://dx.doi.org/10.1084/jem.20112379

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