Expansion of somatically reverted memory CD8(+) T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus

Patients with the primary immunodeficiency X-linked lymphoproliferative disease (XLP), which is caused by mutations in SH2D1A, are highly susceptible to Epstein-Barr virus (EBV) infection. Nonetheless, some XLP patients demonstrate less severe clinical manifestations after primary infection. SH2D1A...

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Detalles Bibliográficos
Autores principales: Palendira, Umaimainthan, Low, Carol, Bell, Andrew I., Ma, Cindy S., Abbott, Rachel J.M., Phan, Tri Giang, Riminton, D. Sean, Choo, Sharon, Smart, Joanne M., Lougaris, Vassilios, Giliani, Silvia, Buckley, Rebecca H., Grimbacher, Bodo, Alvaro, Frank, Klion, Amy D., Nichols, Kim E., Adelstein, Stephen, Rickinson, Alan B., Tangye, Stuart G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348103/
https://www.ncbi.nlm.nih.gov/pubmed/22493517
http://dx.doi.org/10.1084/jem.20112391

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