Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs

Artemis is an endonuclease that opens coding hairpin ends during V(D)J recombination and has critical roles in postirradiation cell survival. A direct role for the C-terminal region of Artemis in V(D)J recombination has not been defined, despite the presence of immunodeficiency and lymphoma developm...

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Detalles Bibliográficos
Autores principales: Malu, Shruti, De Ioannes, Pablo, Kozlov, Mikhail, Greene, Marsha, Francis, Dailia, Hanna, Mary, Pena, Jesse, Escalante, Carlos R., Kurosawa, Aya, Erdjument-Bromage, Hediye, Tempst, Paul, Adachi, Noritaka, Vezzoni, Paolo, Villa, Anna, Aggarwal, Aneel K., Cortes, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348108/
https://www.ncbi.nlm.nih.gov/pubmed/22529269
http://dx.doi.org/10.1084/jem.20111437

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