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Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

The accumulation of misfolded proteins is a fundamental pathogenic process in neurodegenerative diseases. However, the factors that trigger aggregation of α-Synuclein (α-Syn), the principal component of the intraneuronal inclusions known as Lewy bodies (LBs), and Lewy neurites (LNs), which character...

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Detalles Bibliográficos
Autores principales:	Luk, Kelvin C., Kehm, Victoria M., Zhang, Bin, O’Brien, Patrick, Trojanowski, John Q., Lee, Virginia M.Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348112/ https://www.ncbi.nlm.nih.gov/pubmed/22508839 http://dx.doi.org/10.1084/jem.20112457

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