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A role for GPx3 in activity of normal and leukemia stem cells

The determinants of normal and leukemic stem cell self-renewal remain poorly characterized. We report that expression of the reactive oxygen species (ROS) scavenger glutathione peroxidase 3 (GPx3) positively correlates with the frequency of leukemia stem cells (LSCs) in Hoxa9+Meis1-induced leukemias...

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Detalles Bibliográficos
Autores principales:	Herault, Olivier, Hope, Kristin J., Deneault, Eric, Mayotte, Nadine, Chagraoui, Jalila, Wilhelm, Brian T., Cellot, Sonia, Sauvageau, Martin, Andrade-Navarro, Miguel A., Hébert, Josée, Sauvageau, Guy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348115/ https://www.ncbi.nlm.nih.gov/pubmed/22508837 http://dx.doi.org/10.1084/jem.20102386

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