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Risk Factors for Extended Duration of Acute Diarrhea in Young Children

OBJECTIVE AND BACKGROUND: We sought to identify predictors of extended duration of diarrhea in young children, which contributes substantially to the nearly 1 1/2 million annual diarrheal deaths globally. METHODS: We followed 6-35 month old Nepalese children enrolled in the placebo-arm of a randomiz...

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Autores principales: Strand, Tor A., Sharma, Pushpa R., Gjessing, Håkon K., Ulak, Manjeswori, Chandyo, Ram K., Adhikari, Ramesh K., Sommerfelt, Halvor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348155/
https://www.ncbi.nlm.nih.gov/pubmed/22590543
http://dx.doi.org/10.1371/journal.pone.0036436
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author Strand, Tor A.
Sharma, Pushpa R.
Gjessing, Håkon K.
Ulak, Manjeswori
Chandyo, Ram K.
Adhikari, Ramesh K.
Sommerfelt, Halvor
author_facet Strand, Tor A.
Sharma, Pushpa R.
Gjessing, Håkon K.
Ulak, Manjeswori
Chandyo, Ram K.
Adhikari, Ramesh K.
Sommerfelt, Halvor
author_sort Strand, Tor A.
collection PubMed
description OBJECTIVE AND BACKGROUND: We sought to identify predictors of extended duration of diarrhea in young children, which contributes substantially to the nearly 1 1/2 million annual diarrheal deaths globally. METHODS: We followed 6-35 month old Nepalese children enrolled in the placebo-arm of a randomized controlled trial with 391 episodes of acute diarrhea from the day they were diagnosed until cessation of the episode. Using multiple logistic regression analysis, we identified independent risk factors for having diarrhea for more than 7 days after diagnosis. RESULTS: Infants had a 17 (95% CI 3.5, 83)-fold and toddlers (12 to 23 month olds) a 9.9 (95% CI 2.1, 47)-fold higher odds of having such illness duration compared to the older children. Not being breastfed was associated with a 9.3 (95% CI 2.4, 35.7)-fold increase in the odds for this outcome. The odds also increased with increasing stool frequency. Furthermore, having diarrhea in the monsoon season also increased the risk of prolonged illness. CONCLUSION: We found that high stool frequency, not being breastfed, young age and acquiring diarrhea in the rainy season were risk factors for prolonged diarrhea. In populations such as ours, breastfeeding may be the most important modifiable risk factor for extended duration of diarrhea.
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spelling pubmed-33481552012-05-15 Risk Factors for Extended Duration of Acute Diarrhea in Young Children Strand, Tor A. Sharma, Pushpa R. Gjessing, Håkon K. Ulak, Manjeswori Chandyo, Ram K. Adhikari, Ramesh K. Sommerfelt, Halvor PLoS One Research Article OBJECTIVE AND BACKGROUND: We sought to identify predictors of extended duration of diarrhea in young children, which contributes substantially to the nearly 1 1/2 million annual diarrheal deaths globally. METHODS: We followed 6-35 month old Nepalese children enrolled in the placebo-arm of a randomized controlled trial with 391 episodes of acute diarrhea from the day they were diagnosed until cessation of the episode. Using multiple logistic regression analysis, we identified independent risk factors for having diarrhea for more than 7 days after diagnosis. RESULTS: Infants had a 17 (95% CI 3.5, 83)-fold and toddlers (12 to 23 month olds) a 9.9 (95% CI 2.1, 47)-fold higher odds of having such illness duration compared to the older children. Not being breastfed was associated with a 9.3 (95% CI 2.4, 35.7)-fold increase in the odds for this outcome. The odds also increased with increasing stool frequency. Furthermore, having diarrhea in the monsoon season also increased the risk of prolonged illness. CONCLUSION: We found that high stool frequency, not being breastfed, young age and acquiring diarrhea in the rainy season were risk factors for prolonged diarrhea. In populations such as ours, breastfeeding may be the most important modifiable risk factor for extended duration of diarrhea. Public Library of Science 2012-05-08 /pmc/articles/PMC3348155/ /pubmed/22590543 http://dx.doi.org/10.1371/journal.pone.0036436 Text en Strand et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Strand, Tor A.
Sharma, Pushpa R.
Gjessing, Håkon K.
Ulak, Manjeswori
Chandyo, Ram K.
Adhikari, Ramesh K.
Sommerfelt, Halvor
Risk Factors for Extended Duration of Acute Diarrhea in Young Children
title Risk Factors for Extended Duration of Acute Diarrhea in Young Children
title_full Risk Factors for Extended Duration of Acute Diarrhea in Young Children
title_fullStr Risk Factors for Extended Duration of Acute Diarrhea in Young Children
title_full_unstemmed Risk Factors for Extended Duration of Acute Diarrhea in Young Children
title_short Risk Factors for Extended Duration of Acute Diarrhea in Young Children
title_sort risk factors for extended duration of acute diarrhea in young children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348155/
https://www.ncbi.nlm.nih.gov/pubmed/22590543
http://dx.doi.org/10.1371/journal.pone.0036436
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