Cargando…

Growth inhibition induced by antiprogestins RU-38486, ORG-31710, and CDB-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2

Antiprogestins have been largely utilized in reproductive medicine, yet their repositioning for oncologic use is rapidly emerging. In this study we investigated the molecular mediators of the anti-ovarian cancer activity of the structurally related antiprogestins RU-38486, ORG-31710 and CDB-2914. We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goyeneche, Alicia A., Seidel, Erin E., Telleria, Carlos M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2011
Materias:	Preclinical Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348464/ https://www.ncbi.nlm.nih.gov/pubmed/21424700 http://dx.doi.org/10.1007/s10637-011-9655-z

Ejemplares similares

Antiprogestins in gynecological diseases
por: Goyeneche, Alicia A, et al.
Publicado: (2015)

Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression
por: Tieszen, Chelsea R, et al.
Publicado: (2011)

Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicity
por: Gamarra-Luques, Carlos D, et al.
Publicado: (2014)

Antiglucocorticoid RU38486 reduces net protein catabolism in experimental acute renal failure
por: Mondry, Adrian
Publicado: (2005)

New Generation of Meso and Antiprogestins (SPRMs) into the Osteoporosis Approach
por: Woźniczka, Magdalena, et al.
Publicado: (2021)

Resistance to cisplatin does not affect sensitivity of human ovarian cancer cell lines to mifepristone cytotoxicity
por: Freeburg, Elizabeth M, et al.
Publicado: (2009)

CDB installation in the HL-LHC IT STRING
por: Zawilinski, Julian
Publicado: (2022)

Mifepristone inhibits non-small cell lung carcinoma cellular escape from DNA damaging cisplatin
por: Kapperman, Heather E., et al.
Publicado: (2018)

The metastatic capacity of high-grade serous ovarian cancer cells changes along disease progression: inhibition by mifepristone
por: Ritch, Sabrina J., et al.
Publicado: (2022)

G2Cdb: the Genes to Cognition database
por: Croning, Mike D. R., et al.
Publicado: (2009)

Population Pharmacokinetics of Telapristone (CDB-4124) and its Active Monodemethylated Metabolite CDB-4453, with a Mixture Model for Total Clearance
por: Morris, Denise, et al.
Publicado: (2011)

Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy
por: Goyeneche, Alicia A, et al.
Publicado: (2012)

CDB - Distributed Conditions Database of BaBar Experiment
por: Gaponenko, I A, et al.
Publicado: (2005)

MicroRNA-195 reverses the resistance to temozolomide through targeting cyclin E1 in glioma cells
por: Wang, Hongqin, et al.
Publicado: (2019)

Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
por: Bartlett, Thomas E., et al.
Publicado: (2022)

Optogenetic inhibition of cocaine seeking in rats
por: Stefanik, Michael T, et al.
Publicado: (2013)

The clinical significance of cyclin B1 (CCNB1) in invasive breast cancer with emphasis on its contribution to lymphovascular invasion development
por: Aljohani, Abrar I., et al.
Publicado: (2022)

H(2) Inhibits the Formation of Neutrophil Extracellular Traps
por: Shirakawa, Kohsuke, et al.
Publicado: (2022)

Correction: Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
por: Bartlett, Thomas E., et al.
Publicado: (2022)

Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide
por: Oerlemans, Ruud, et al.
Publicado: (2018)

Exogenous estradiol enhances apoptosis in regressing post-partum rat corpora lutea possibly mediated by prolactin
por: Goyeneche, Alicia A, et al.
Publicado: (2005)

Myeloperoxidase Inhibition Improves Ventricular Function and Remodeling After Experimental Myocardial Infarction
por: Ali, Muhammad, et al.
Publicado: (2016)

Tectorigenin inhibits osteosarcoma cell migration through downregulation of matrix metalloproteinases in vitro
por: Guo, Yu, et al.
Publicado: (2016)

3-Methyladenine-enhanced susceptibility to sorafenib in hepatocellular carcinoma cells by inhibiting autophagy
por: Zhao, Fangfang, et al.
Publicado: (2021)

Flexible heteroarotinoid (Flex-Het) SHetA2 inhibits angiogenesis in vitro and in vivo
por: Myers, Tashanna, et al.
Publicado: (2008)

Neutralization of the CD95 ligand by APG101 inhibits invasion of glioma cells in vitro
por: Merz, Christian, et al.
Publicado: (2015)

Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction
por: Wang, Wei, et al.
Publicado: (2019)

Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition
por: Francisco, Jamie, et al.
Publicado: (2020)

PERK Inhibition Mitigates Restenosis and Thrombosis: A Potential Low-Thrombogenic Antirestenotic Paradigm
por: Wang, Bowen, et al.
Publicado: (2020)

Chemo-sensitisation of HeLa cells to Etoposide by a Benzoxazine in the absence of DNA-PK inhibition
por: Fitzgibbon, Cheree, et al.
Publicado: (2013)

Evodiamine inhibits migration and invasion by Sirt1-mediated post-translational modulations in colorectal cancer
por: Zhou, Peng, et al.
Publicado: (2019)

Cardiac Versus Renal Response to Volume Expansion in Preclinical Systolic Dysfunction With PDEV Inhibition and BNP
por: Wan, Siu-Hin, et al.
Publicado: (2019)

Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition
por: Soranno, Danielle E., et al.
Publicado: (2021)

Targeting IL-6 Trans-Signaling: Amplifying the Benefits of IL-6 Inhibition in Myocardial Infarction
por: Aukrust, Pål, et al.
Publicado: (2021)

Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes
por: Friedland, Julie C., et al.
Publicado: (2013)

Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction
por: Vainio, Laura E., et al.
Publicado: (2019)

Multi-targeted kinase inhibition alleviates mTOR inhibitor resistance in triple-negative breast cancer
por: He, Jichao, et al.
Publicado: (2019)

Celastrol Alleviates Aortic Valve Calcification Via Inhibition of NADPH Oxidase 2 in Valvular Interstitial Cells
por: Liu, Huibing, et al.
Publicado: (2019)

NLRP3 Inflammasome Inhibition: A Potential Therapeutic Strategy to Attenuate Postinfarction Adverse Cardiac Remodeling
por: Narendran, Siddharth, et al.
Publicado: (2020)

Nelfinavir Induces Cytotoxicity towards High-Grade Serous Ovarian Cancer Cells, Involving Induction of the Unfolded Protein Response, Modulation of Protein Synthesis, DNA Damage, Lysosomal Impairment, and Potentiation of Toxicity Caused by Proteasome Inhibition
por: Subeha, Mahbuba R., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ck0t3djbacdtf3liotre7hs2tr