A Micro-RNA Connection in BRaf (V600E)-Mediated Premature Senescence of Human Melanocytes

Recent high-throughput-sequencing of the cancer genome has identified oncogenic mutations in BRaf genetic locus as one of the critical events in melanomagenesis. In normal cells, the activity of BRaf is tightly regulated. Gain-of-function mutations like those identified in melanoma frequently lead t...

Descripción completa

Detalles Bibliográficos
Autores principales: Ren, Gang, Feng, Jingwei, Datar, Ila, Yeung, Aaron H., Saladi, Srinivas Vinod, Feng, Yongqing, de la Serna, Ivana, Yeung, Kam C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348633/
https://www.ncbi.nlm.nih.gov/pubmed/22611400
http://dx.doi.org/10.1155/2012/913242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348633/
https://www.ncbi.nlm.nih.gov/pubmed/22611400
http://dx.doi.org/10.1155/2012/913242

Ejemplares similares