NOXA-Induced Alterations in the Bax/Smac Axis Enhance Sensitivity of Ovarian Cancer Cells to Cisplatin

Ovarian cancer is the most common cause of death from gynecologic malignancy. Deregulation of p53 and/or p73-associated apoptotic pathways contribute to the platinum-based resistance in ovarian cancer. NOXA, a pro-apoptotic BH3-only protein, is identified as a transcription target of p53 and/or p73....

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Detalles Bibliográficos
Autores principales: Lin, Chao, Zhao, Xin-yu, Li, Lei, Liu, Huan-yi, Cao, Kang, Wan, Yang, Liu, Xin-yu, Nie, Chun-lai, Liu, Lei, Tong, Ai-ping, Deng, Hong-xin, Li, Jiong, Yuan, Zhu, Wei, Yu-quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348888/
https://www.ncbi.nlm.nih.gov/pubmed/22590594
http://dx.doi.org/10.1371/journal.pone.0036722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348888/
https://www.ncbi.nlm.nih.gov/pubmed/22590594
http://dx.doi.org/10.1371/journal.pone.0036722

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