Human Peripheral Blood Antibodies with Long HCDR3s Are Established Primarily at Original Recombination Using a Limited Subset of Germline Genes

A number of antibodies that efficiently neutralize microbial targets contain long heavy chain complementarity determining region 3 (HCDR3) loops. For HIV, several of the most broad and potently neutralizing antibodies have exceptionally long HCDR3s. Two broad potently neutralizing HIV-specific antib...

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Detalles Bibliográficos
Autores principales: Briney, Bryan S., Willis, Jordan R., Crowe, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348910/
https://www.ncbi.nlm.nih.gov/pubmed/22590602
http://dx.doi.org/10.1371/journal.pone.0036750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348910/
https://www.ncbi.nlm.nih.gov/pubmed/22590602
http://dx.doi.org/10.1371/journal.pone.0036750

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