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A Bodyweight-Dependent Allometric Exponent for Scaling Clearance Across the Human Life-Span

PURPOSE: To explore different allometric equations for scaling clearance across the human life-span using propofol as a model drug. METHODS: Data from seven previously published propofol studies ((pre)term neonates, infants, toddlers, children, adolescents and adults) were analysed using NONMEM VI....

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Detalles Bibliográficos
Autores principales:	Wang, Chenguang, Peeters, Mariska Y. M., Allegaert, Karel, Blussé van Oud-Alblas, Heleen J., Krekels, Elke H. J., Tibboel, Dick, Danhof, Meindert, Knibbe, Catherijne A. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2012
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349030/ https://www.ncbi.nlm.nih.gov/pubmed/22287046 http://dx.doi.org/10.1007/s11095-012-0668-x

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