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Bladder Mucosal CO(2) Compared with Gastric Mucosal CO(2) as a Marker for Low Perfusion States in Septic Shock

Recent reports indicate the possible role of bladder CO(2) as a marker of low perfusion states. To test this hypothesis, shock was induced in six beagle dogs with 1 mg/kg of E. coli lipopolysaccharide, gastric CO(2) (CO(2)-G) was measured with a continuous monitor, and a pulmonary catheter was inser...

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Detalles Bibliográficos
Autores principales: Seller-Pérez, Gemma, Herrera-Gutiérrez, Manuel E., Aragón-González, Cesar, Granados, Maria M., Dominguez, Juan M., Navarrete, Rocío, Quesada-García, Guillermo, Morgaz, Juán, Gómez-Villamandos, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349138/
https://www.ncbi.nlm.nih.gov/pubmed/22593678
http://dx.doi.org/10.1100/2012/360378
Descripción
Sumario:Recent reports indicate the possible role of bladder CO(2) as a marker of low perfusion states. To test this hypothesis, shock was induced in six beagle dogs with 1 mg/kg of E. coli lipopolysaccharide, gastric CO(2) (CO(2)-G) was measured with a continuous monitor, and a pulmonary catheter was inserted in the bladder to measure CO(2) (CO(2)-B). Levels of CO(2)-B were found to be lower than those of CO(2)-G, with a mean difference of 36.8 mmHg (P < 0.001), and correlation between both measurements was poor (r (2) = 0.16). Even when the correlation between CO(2)-G and ΔCO(2)-G was narrow (r (2) = 0.86), this was not the case for the relationship between CO(2)-B and ΔCO(2)-B (r (2) = 0.29). Finally, the correlation between CO(2)-G and base deficit was good (r (2) = 0.45), which was not the case with the CO(2)-B correlation (r (2) = 0.03). In our experience, bladder CO(2) does not correlate to hemodynamic parameters and does not substitute gastric CO(2) for detection of low perfusion states.