AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells

PPARαs are nuclear receptors highly expressed in colon cells. They can be activated by the fibrates (clofibrate, ciprofibrate etc.) used to treat hyperlipidemia. Since PPARα transcriptional activity can be negatively regulated by JNK, the inhibition of JNK activity could increase the effectiveness o...

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Detalles Bibliográficos
Autores principales: Cerbone, Angelo, Toaldo, Cristina, Pizzimenti, Stefania, Pettazzoni, Piergiorgio, Dianzani, Chiara, Minelli, Rosalba, Ciamporcero, Eric, Roma, Guglielmo, Dianzani, Mario Umberto, Canaparo, Roberto, Ferretti, Carlo, Barrera, Giuseppina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349252/
https://www.ncbi.nlm.nih.gov/pubmed/22619672
http://dx.doi.org/10.1155/2012/269751

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