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Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

BACKGROUND: There is overwhelming evidence that in vitro three-dimensional tumor cell cultures more accurately reflect the complex in vivo microenvironment than simple two-dimensional cell monolayers, not least with respect to gene expression profiles, signaling pathway activity and drug sensitivity...

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Detalles Bibliográficos
Autores principales:	Vinci, Maria, Gowan, Sharon, Boxall, Frances, Patterson, Lisa, Zimmermann, Miriam, Court, William, Lomas, Cara, Mendiola, Marta, Hardisson, David, Eccles, Suzanne A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349530/ https://www.ncbi.nlm.nih.gov/pubmed/22439642 http://dx.doi.org/10.1186/1741-7007-10-29

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