Modification of Cyclic NGR Tumor Neovasculature-Homing Motif Sequence to Human Plasminogen Kringle 5 Improves Inhibition of Tumor Growth

BACKGROUND: Blood vessels in tumors express higher level of aminopeptidase N (APN) than normal tissues. Evidence suggests that the CNGRC motif is an APN ligand which targets tumor vasculature. Increased expression of APN in tumor vascular endothelium, therefore, offers an opportunity for targeted de...

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Detalles Bibliográficos
Autores principales: Jiang, Weiwei, Jin, Guanghui, Ma, Dingyuan, Wang, Feng, Fu, Tong, Chen, Xiao, Chen, Xiwen, Jia, Kunzhi, Marikar, Faiz M. M. T., Hua, Zichun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349653/
https://www.ncbi.nlm.nih.gov/pubmed/22590653
http://dx.doi.org/10.1371/journal.pone.0037132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349653/
https://www.ncbi.nlm.nih.gov/pubmed/22590653
http://dx.doi.org/10.1371/journal.pone.0037132

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