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Modeling HIV-1 Drug Resistance as Episodic Directional Selection

The evolution of substitutions conferring drug resistance to HIV-1 is both episodic, occurring when patients are on antiretroviral therapy, and strongly directional, with site-specific resistant residues increasing in frequency over time. While methods exist to detect episodic diversifying selection...

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Detalles Bibliográficos
Autores principales:	Murrell, Ben, de Oliveira, Tulio, Seebregts, Chris, Kosakovsky Pond, Sergei L., Scheffler, Konrad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349733/ https://www.ncbi.nlm.nih.gov/pubmed/22589711 http://dx.doi.org/10.1371/journal.pcbi.1002507

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