The Effect of Human Factor H on Immunogenicity of Meningococcal Native Outer Membrane Vesicle Vaccines with Over-Expressed Factor H Binding Protein

The binding of human complement inhibitors to vaccine antigens in vivo could diminish their immunogenicity. A meningococcal ligand for the complement down-regulator, factor H (fH), is fH-binding protein (fHbp), which is specific for human fH. Vaccines containing recombinant fHbp or native outer memb...

Descripción completa

Detalles Bibliográficos
Autores principales: Beernink, Peter T., Shaughnessy, Jutamas, Pajon, Rolando, Braga, Emily M., Ram, Sanjay, Granoff, Dan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349754/
https://www.ncbi.nlm.nih.gov/pubmed/22589720
http://dx.doi.org/10.1371/journal.ppat.1002688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349754/
https://www.ncbi.nlm.nih.gov/pubmed/22589720
http://dx.doi.org/10.1371/journal.ppat.1002688

Ejemplares similares