Epstein-Barr Virus Infection of Naïve B Cells In Vitro Frequently Selects Clones with Mutated Immunoglobulin Genotypes: Implications for Virus Biology

Epstein-Barr virus (EBV), a lymphomagenic human herpesvirus, colonises the host through polyclonal B cell-growth-transforming infections yet establishes persistence only in IgD(+) CD27(+) non-switched memory (NSM) and IgD(−) CD27(+) switched memory (SM) B cells, not in IgD(+) CD27(−) naïve (N) cells...

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Detalles Bibliográficos
Autores principales: Heath, Emily, Begue-Pastor, Noelia, Chaganti, Sridhar, Croom-Carter, Debbie, Shannon-Lowe, Claire, Kube, Dieter, Feederle, Regina, Delecluse, Henri-Jacques, Rickinson, Alan B., Bell, Andrew I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349760/
https://www.ncbi.nlm.nih.gov/pubmed/22589726
http://dx.doi.org/10.1371/journal.ppat.1002697

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