IL-13 Signaling in Liver Fibrogenesis

Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directl...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yan, Munker, Stefan, Müllenbach, Roman, Weng, Hong-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349963/
https://www.ncbi.nlm.nih.gov/pubmed/22593760
http://dx.doi.org/10.3389/fimmu.2012.00116
_version_ 1782232578448687104
author Liu, Yan
Munker, Stefan
Müllenbach, Roman
Weng, Hong-Lei
author_facet Liu, Yan
Munker, Stefan
Müllenbach, Roman
Weng, Hong-Lei
author_sort Liu, Yan
collection PubMed
description Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directly induces expression of fibrosis-associated genes, e.g., collagens or connective tissue growth factor, in hepatic stellate cells. Recently, potential effects of IL-13 in non-Schistosomiasis associated liver fibrosis have been uncovered. This review summarizes the potential roles of IL-13 in chronic liver disease of different etiologies, and the downstream events mediating IL-13 signaling in liver fibrogenesis.
format Online
Article
Text
id pubmed-3349963
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Frontiers Research Foundation
record_format MEDLINE/PubMed
spelling pubmed-33499632012-05-16 IL-13 Signaling in Liver Fibrogenesis Liu, Yan Munker, Stefan Müllenbach, Roman Weng, Hong-Lei Front Immunol Immunology Liver fibrosis is the final common pathway of chronic liver diseases irrespective of etiology. However, etiology deeply impacts progression and characteristics of liver fibrogenesis. IL-13 is the dominant pro-fibrotic cytokine in Schistosomiasis associated liver fibrogenesis. In vitro, IL-13 directly induces expression of fibrosis-associated genes, e.g., collagens or connective tissue growth factor, in hepatic stellate cells. Recently, potential effects of IL-13 in non-Schistosomiasis associated liver fibrosis have been uncovered. This review summarizes the potential roles of IL-13 in chronic liver disease of different etiologies, and the downstream events mediating IL-13 signaling in liver fibrogenesis. Frontiers Research Foundation 2012-05-11 /pmc/articles/PMC3349963/ /pubmed/22593760 http://dx.doi.org/10.3389/fimmu.2012.00116 Text en Copyright © 2012 Liu, Munker, Müllenbach and Weng. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Immunology
Liu, Yan
Munker, Stefan
Müllenbach, Roman
Weng, Hong-Lei
IL-13 Signaling in Liver Fibrogenesis
title IL-13 Signaling in Liver Fibrogenesis
title_full IL-13 Signaling in Liver Fibrogenesis
title_fullStr IL-13 Signaling in Liver Fibrogenesis
title_full_unstemmed IL-13 Signaling in Liver Fibrogenesis
title_short IL-13 Signaling in Liver Fibrogenesis
title_sort il-13 signaling in liver fibrogenesis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349963/
https://www.ncbi.nlm.nih.gov/pubmed/22593760
http://dx.doi.org/10.3389/fimmu.2012.00116
work_keys_str_mv AT liuyan il13signalinginliverfibrogenesis
AT munkerstefan il13signalinginliverfibrogenesis
AT mullenbachroman il13signalinginliverfibrogenesis
AT wenghonglei il13signalinginliverfibrogenesis

Ejemplares similares