Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models

Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and present studies that have contributed to our current appreciation of the important roles adrenomedull...

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Autores principales: Karpinich, Natalie O, Hoopes, Samantha L, Kechele, Daniel O, Lenhart, Patricia M, Caron, Kathleen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349984/
https://www.ncbi.nlm.nih.gov/pubmed/22582036
http://dx.doi.org/10.2174/157340211799304761
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author Karpinich, Natalie O
Hoopes, Samantha L
Kechele, Daniel O
Lenhart, Patricia M
Caron, Kathleen M
author_facet Karpinich, Natalie O
Hoopes, Samantha L
Kechele, Daniel O
Lenhart, Patricia M
Caron, Kathleen M
author_sort Karpinich, Natalie O
collection PubMed
description Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and present studies that have contributed to our current appreciation of the important roles adrenomedullin plays in both normal and disease conditions. We provide a particular emphasis on the functions of adrenomedullin in vascular endothelial cells and how experimental approaches in genetic mouse models have helped to drive the field forward.
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spelling pubmed-33499842012-05-11 Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models Karpinich, Natalie O Hoopes, Samantha L Kechele, Daniel O Lenhart, Patricia M Caron, Kathleen M Curr Hypertens Rev Article Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and present studies that have contributed to our current appreciation of the important roles adrenomedullin plays in both normal and disease conditions. We provide a particular emphasis on the functions of adrenomedullin in vascular endothelial cells and how experimental approaches in genetic mouse models have helped to drive the field forward. Bentham Science Publishers 2011-12 2011-12 /pmc/articles/PMC3349984/ /pubmed/22582036 http://dx.doi.org/10.2174/157340211799304761 Text en © 2011 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Karpinich, Natalie O
Hoopes, Samantha L
Kechele, Daniel O
Lenhart, Patricia M
Caron, Kathleen M
Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models
title Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models
title_full Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models
title_fullStr Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models
title_full_unstemmed Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models
title_short Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models
title_sort adrenomedullin function in vascular endothelial cells: insights from genetic mouse models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349984/
https://www.ncbi.nlm.nih.gov/pubmed/22582036
http://dx.doi.org/10.2174/157340211799304761
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