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Primary Synovial Sarcoma of the Mediastinum : A Case Report
Synovial sarcomas commonly occur in the extremities of young adults. A primary occurrence in the mediastinum is very rare with only a few reported cases in the world literature. This paper is about a 42-year-old male who presented with chest pain and dyspnoea on exertion. Imaging showed an anterior...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350037/ https://www.ncbi.nlm.nih.gov/pubmed/22606585 http://dx.doi.org/10.1155/2011/602853 |
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author | Ravikumar, Gayatri Mullick, Shalini Ananthamurthy, Anuradha Correa, Marjorie |
author_facet | Ravikumar, Gayatri Mullick, Shalini Ananthamurthy, Anuradha Correa, Marjorie |
author_sort | Ravikumar, Gayatri |
collection | PubMed |
description | Synovial sarcomas commonly occur in the extremities of young adults. A primary occurrence in the mediastinum is very rare with only a few reported cases in the world literature. This paper is about a 42-year-old male who presented with chest pain and dyspnoea on exertion. Imaging showed an anterior mediastinal mass with adhesions to the lung. Pathological examination of the resected mass showed a biphasic neoplasm with a spindle cell component admixed with gland-like elements. The tumour showed positive staining with cytokeratin, epithelial membrane antigen, and Bcl-2 confirming the diagnosis of a biphasic synovial sarcoma. A wide range of neoplasms, both primary and metastatic, occur in the mediastinum, which pose considerable diagnostic difficulties. A synovial sarcoma should always be considered in the differential diagnosis, and immunohistochemistry is an important adjuvant tool in this situation. This paper highlights the importance of recognizing an unusual presentation of this aggressive neoplasm to aid appropriate clinical management. |
format | Online Article Text |
id | pubmed-3350037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33500372012-05-17 Primary Synovial Sarcoma of the Mediastinum : A Case Report Ravikumar, Gayatri Mullick, Shalini Ananthamurthy, Anuradha Correa, Marjorie Case Rep Surg Case Report Synovial sarcomas commonly occur in the extremities of young adults. A primary occurrence in the mediastinum is very rare with only a few reported cases in the world literature. This paper is about a 42-year-old male who presented with chest pain and dyspnoea on exertion. Imaging showed an anterior mediastinal mass with adhesions to the lung. Pathological examination of the resected mass showed a biphasic neoplasm with a spindle cell component admixed with gland-like elements. The tumour showed positive staining with cytokeratin, epithelial membrane antigen, and Bcl-2 confirming the diagnosis of a biphasic synovial sarcoma. A wide range of neoplasms, both primary and metastatic, occur in the mediastinum, which pose considerable diagnostic difficulties. A synovial sarcoma should always be considered in the differential diagnosis, and immunohistochemistry is an important adjuvant tool in this situation. This paper highlights the importance of recognizing an unusual presentation of this aggressive neoplasm to aid appropriate clinical management. Hindawi Publishing Corporation 2011 2011-09-07 /pmc/articles/PMC3350037/ /pubmed/22606585 http://dx.doi.org/10.1155/2011/602853 Text en Copyright © 2011 Gayatri Ravikumar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Ravikumar, Gayatri Mullick, Shalini Ananthamurthy, Anuradha Correa, Marjorie Primary Synovial Sarcoma of the Mediastinum : A Case Report |
title | Primary Synovial Sarcoma of the Mediastinum : A Case Report |
title_full | Primary Synovial Sarcoma of the Mediastinum : A Case Report |
title_fullStr | Primary Synovial Sarcoma of the Mediastinum : A Case Report |
title_full_unstemmed | Primary Synovial Sarcoma of the Mediastinum : A Case Report |
title_short | Primary Synovial Sarcoma of the Mediastinum : A Case Report |
title_sort | primary synovial sarcoma of the mediastinum : a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350037/ https://www.ncbi.nlm.nih.gov/pubmed/22606585 http://dx.doi.org/10.1155/2011/602853 |
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