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Altered Tryptophan Metabolism as a Paradigm for Good and Bad Aspects of Immune Privilege in Chronic Inflammatory Diseases
The term “immune privilege” was coined to describe weak immunogenicity (hypo-immunity) that manifests in some transplant settings. We extended this concept to encompass hypo-immunity that manifests at local sites of inflammation relevant to clinical diseases. Here, we focus on emerging evidence that...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350084/ https://www.ncbi.nlm.nih.gov/pubmed/22593757 http://dx.doi.org/10.3389/fimmu.2012.00109 |
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author | Li, Lingqian Huang, Lei Lemos, Henrique P. Mautino, Mario Mellor, Andrew L. |
author_facet | Li, Lingqian Huang, Lei Lemos, Henrique P. Mautino, Mario Mellor, Andrew L. |
author_sort | Li, Lingqian |
collection | PubMed |
description | The term “immune privilege” was coined to describe weak immunogenicity (hypo-immunity) that manifests in some transplant settings. We extended this concept to encompass hypo-immunity that manifests at local sites of inflammation relevant to clinical diseases. Here, we focus on emerging evidence that enhanced tryptophan catabolism is a key metabolic process that promotes and sustains induced immune privilege, and discuss the implications for exploiting this knowledge to improve treatments for hypo-immune and hyper-immune syndromes using strategies to manipulate tryptophan metabolism. |
format | Online Article Text |
id | pubmed-3350084 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33500842012-05-16 Altered Tryptophan Metabolism as a Paradigm for Good and Bad Aspects of Immune Privilege in Chronic Inflammatory Diseases Li, Lingqian Huang, Lei Lemos, Henrique P. Mautino, Mario Mellor, Andrew L. Front Immunol Immunology The term “immune privilege” was coined to describe weak immunogenicity (hypo-immunity) that manifests in some transplant settings. We extended this concept to encompass hypo-immunity that manifests at local sites of inflammation relevant to clinical diseases. Here, we focus on emerging evidence that enhanced tryptophan catabolism is a key metabolic process that promotes and sustains induced immune privilege, and discuss the implications for exploiting this knowledge to improve treatments for hypo-immune and hyper-immune syndromes using strategies to manipulate tryptophan metabolism. Frontiers Research Foundation 2012-05-11 /pmc/articles/PMC3350084/ /pubmed/22593757 http://dx.doi.org/10.3389/fimmu.2012.00109 Text en Copyright © 2012 Li, Huang, Lemos, Mautino and Mellor. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Immunology Li, Lingqian Huang, Lei Lemos, Henrique P. Mautino, Mario Mellor, Andrew L. Altered Tryptophan Metabolism as a Paradigm for Good and Bad Aspects of Immune Privilege in Chronic Inflammatory Diseases |
title | Altered Tryptophan Metabolism as a Paradigm for Good and Bad Aspects of Immune Privilege in Chronic Inflammatory Diseases |
title_full | Altered Tryptophan Metabolism as a Paradigm for Good and Bad Aspects of Immune Privilege in Chronic Inflammatory Diseases |
title_fullStr | Altered Tryptophan Metabolism as a Paradigm for Good and Bad Aspects of Immune Privilege in Chronic Inflammatory Diseases |
title_full_unstemmed | Altered Tryptophan Metabolism as a Paradigm for Good and Bad Aspects of Immune Privilege in Chronic Inflammatory Diseases |
title_short | Altered Tryptophan Metabolism as a Paradigm for Good and Bad Aspects of Immune Privilege in Chronic Inflammatory Diseases |
title_sort | altered tryptophan metabolism as a paradigm for good and bad aspects of immune privilege in chronic inflammatory diseases |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350084/ https://www.ncbi.nlm.nih.gov/pubmed/22593757 http://dx.doi.org/10.3389/fimmu.2012.00109 |
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