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Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency

Congenital adrenal hyperplasia (CAH) describes a group of inherited autosomal recessive disorders characterized by enzyme defects in the steroidogenic pathways that lead to the biosynthesis of cortisol, aldosterone, and androgens. Chronic excessive adrenocorticotropic hormone (ACTH) stimulation may...

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Autores principales: Charfi, Nadia, Kamoun, Mahdi, Feki Mnif, Mouna, Mseddi, Neila, Mnif, Fatma, Kallel, Nozha, Ben Naceur, Basma, Rekik, Nabila, Fourati, Hela, Daoud, Emna, Mnif, Zainab, Hadj Sliman, Mourad, Sellami-Boudawara, Tahia, Abid, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350130/
https://www.ncbi.nlm.nih.gov/pubmed/22606635
http://dx.doi.org/10.1155/2012/648643
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author Charfi, Nadia
Kamoun, Mahdi
Feki Mnif, Mouna
Mseddi, Neila
Mnif, Fatma
Kallel, Nozha
Ben Naceur, Basma
Rekik, Nabila
Fourati, Hela
Daoud, Emna
Mnif, Zainab
Hadj Sliman, Mourad
Sellami-Boudawara, Tahia
Abid, Mohamed
author_facet Charfi, Nadia
Kamoun, Mahdi
Feki Mnif, Mouna
Mseddi, Neila
Mnif, Fatma
Kallel, Nozha
Ben Naceur, Basma
Rekik, Nabila
Fourati, Hela
Daoud, Emna
Mnif, Zainab
Hadj Sliman, Mourad
Sellami-Boudawara, Tahia
Abid, Mohamed
author_sort Charfi, Nadia
collection PubMed
description Congenital adrenal hyperplasia (CAH) describes a group of inherited autosomal recessive disorders characterized by enzyme defects in the steroidogenic pathways that lead to the biosynthesis of cortisol, aldosterone, and androgens. Chronic excessive adrenocorticotropic hormone (ACTH) stimulation may result in hyperplasia of ACTH-sensitive tissues in adrenal glands and other sites such as the testes, causing testicular masses known as testicular adrenal rest tumors (TARTs). Leydig cell tumors (LCTs) are make up a very small number of all testicular tumors and can be difficult to distinguish from TARTs. This distinction is interesting because LCTs and TARTs require different therapeutic approaches. Hereby, we present an unusual case of a 19-year-old patient with CAH due to 11β-hydroxylase deficiency, who presented with TARTs and an epididymal Leydig cell tumor.
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spelling pubmed-33501302012-05-17 Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency Charfi, Nadia Kamoun, Mahdi Feki Mnif, Mouna Mseddi, Neila Mnif, Fatma Kallel, Nozha Ben Naceur, Basma Rekik, Nabila Fourati, Hela Daoud, Emna Mnif, Zainab Hadj Sliman, Mourad Sellami-Boudawara, Tahia Abid, Mohamed Case Rep Urol Case Report Congenital adrenal hyperplasia (CAH) describes a group of inherited autosomal recessive disorders characterized by enzyme defects in the steroidogenic pathways that lead to the biosynthesis of cortisol, aldosterone, and androgens. Chronic excessive adrenocorticotropic hormone (ACTH) stimulation may result in hyperplasia of ACTH-sensitive tissues in adrenal glands and other sites such as the testes, causing testicular masses known as testicular adrenal rest tumors (TARTs). Leydig cell tumors (LCTs) are make up a very small number of all testicular tumors and can be difficult to distinguish from TARTs. This distinction is interesting because LCTs and TARTs require different therapeutic approaches. Hereby, we present an unusual case of a 19-year-old patient with CAH due to 11β-hydroxylase deficiency, who presented with TARTs and an epididymal Leydig cell tumor. Hindawi Publishing Corporation 2012 2012-02-12 /pmc/articles/PMC3350130/ /pubmed/22606635 http://dx.doi.org/10.1155/2012/648643 Text en Copyright © 2012 Nadia Charfi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Charfi, Nadia
Kamoun, Mahdi
Feki Mnif, Mouna
Mseddi, Neila
Mnif, Fatma
Kallel, Nozha
Ben Naceur, Basma
Rekik, Nabila
Fourati, Hela
Daoud, Emna
Mnif, Zainab
Hadj Sliman, Mourad
Sellami-Boudawara, Tahia
Abid, Mohamed
Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency
title Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency
title_full Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency
title_fullStr Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency
title_full_unstemmed Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency
title_short Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency
title_sort leydig cell tumor associated with testicular adrenal rest tumors in a patient with congenital adrenal hyperplasia due to 11β-hydroxylase deficiency
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350130/
https://www.ncbi.nlm.nih.gov/pubmed/22606635
http://dx.doi.org/10.1155/2012/648643
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