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Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency
Congenital adrenal hyperplasia (CAH) describes a group of inherited autosomal recessive disorders characterized by enzyme defects in the steroidogenic pathways that lead to the biosynthesis of cortisol, aldosterone, and androgens. Chronic excessive adrenocorticotropic hormone (ACTH) stimulation may...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350130/ https://www.ncbi.nlm.nih.gov/pubmed/22606635 http://dx.doi.org/10.1155/2012/648643 |
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author | Charfi, Nadia Kamoun, Mahdi Feki Mnif, Mouna Mseddi, Neila Mnif, Fatma Kallel, Nozha Ben Naceur, Basma Rekik, Nabila Fourati, Hela Daoud, Emna Mnif, Zainab Hadj Sliman, Mourad Sellami-Boudawara, Tahia Abid, Mohamed |
author_facet | Charfi, Nadia Kamoun, Mahdi Feki Mnif, Mouna Mseddi, Neila Mnif, Fatma Kallel, Nozha Ben Naceur, Basma Rekik, Nabila Fourati, Hela Daoud, Emna Mnif, Zainab Hadj Sliman, Mourad Sellami-Boudawara, Tahia Abid, Mohamed |
author_sort | Charfi, Nadia |
collection | PubMed |
description | Congenital adrenal hyperplasia (CAH) describes a group of inherited autosomal recessive disorders characterized by enzyme defects in the steroidogenic pathways that lead to the biosynthesis of cortisol, aldosterone, and androgens. Chronic excessive adrenocorticotropic hormone (ACTH) stimulation may result in hyperplasia of ACTH-sensitive tissues in adrenal glands and other sites such as the testes, causing testicular masses known as testicular adrenal rest tumors (TARTs). Leydig cell tumors (LCTs) are make up a very small number of all testicular tumors and can be difficult to distinguish from TARTs. This distinction is interesting because LCTs and TARTs require different therapeutic approaches. Hereby, we present an unusual case of a 19-year-old patient with CAH due to 11β-hydroxylase deficiency, who presented with TARTs and an epididymal Leydig cell tumor. |
format | Online Article Text |
id | pubmed-3350130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33501302012-05-17 Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency Charfi, Nadia Kamoun, Mahdi Feki Mnif, Mouna Mseddi, Neila Mnif, Fatma Kallel, Nozha Ben Naceur, Basma Rekik, Nabila Fourati, Hela Daoud, Emna Mnif, Zainab Hadj Sliman, Mourad Sellami-Boudawara, Tahia Abid, Mohamed Case Rep Urol Case Report Congenital adrenal hyperplasia (CAH) describes a group of inherited autosomal recessive disorders characterized by enzyme defects in the steroidogenic pathways that lead to the biosynthesis of cortisol, aldosterone, and androgens. Chronic excessive adrenocorticotropic hormone (ACTH) stimulation may result in hyperplasia of ACTH-sensitive tissues in adrenal glands and other sites such as the testes, causing testicular masses known as testicular adrenal rest tumors (TARTs). Leydig cell tumors (LCTs) are make up a very small number of all testicular tumors and can be difficult to distinguish from TARTs. This distinction is interesting because LCTs and TARTs require different therapeutic approaches. Hereby, we present an unusual case of a 19-year-old patient with CAH due to 11β-hydroxylase deficiency, who presented with TARTs and an epididymal Leydig cell tumor. Hindawi Publishing Corporation 2012 2012-02-12 /pmc/articles/PMC3350130/ /pubmed/22606635 http://dx.doi.org/10.1155/2012/648643 Text en Copyright © 2012 Nadia Charfi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Charfi, Nadia Kamoun, Mahdi Feki Mnif, Mouna Mseddi, Neila Mnif, Fatma Kallel, Nozha Ben Naceur, Basma Rekik, Nabila Fourati, Hela Daoud, Emna Mnif, Zainab Hadj Sliman, Mourad Sellami-Boudawara, Tahia Abid, Mohamed Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency |
title | Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency |
title_full | Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency |
title_fullStr | Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency |
title_full_unstemmed | Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency |
title_short | Leydig Cell Tumor Associated with Testicular Adrenal Rest Tumors in a Patient with Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency |
title_sort | leydig cell tumor associated with testicular adrenal rest tumors in a patient with congenital adrenal hyperplasia due to 11β-hydroxylase deficiency |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350130/ https://www.ncbi.nlm.nih.gov/pubmed/22606635 http://dx.doi.org/10.1155/2012/648643 |
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