Vancomycin Hypersensitivity Diagnosed by Lymphocyte Blast Transformation

A 15-year-old male admitted for Pott's puffy tumor developed recurrent episodes of fever, diffuse morbilliform rash, eosinophilia, and tubulointerstitial nephritis while on multiple antibiotics. Lymphocyte blast transformation (LBT), a method of detecting cellular immune response by measuring l...

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Detalles Bibliográficos
Autores principales: Tran, Nguyen P., Katcher, Jeremy, Rohman, Erin, Hall, Mary Francis, Michael, Christie F., Miyairi, Isao, Lew, D. Betty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350173/
https://www.ncbi.nlm.nih.gov/pubmed/22606516
http://dx.doi.org/10.1155/2011/562620
Descripción
Sumario:A 15-year-old male admitted for Pott's puffy tumor developed recurrent episodes of fever, diffuse morbilliform rash, eosinophilia, and tubulointerstitial nephritis while on multiple antibiotics. Lymphocyte blast transformation (LBT), a method of detecting cellular immune response by measuring levels of interferon-γ (IFN-γ), was used to diagnose vancomycin hypersensitivity and guide antibiotic selection.

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