Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents

[Image: see text] On the basis of the initial success of optimization of a novel series of imidazolopiperazines, a second generation of compounds involving changes in the core piperazine ring was synthesized to improve antimalarial properties. These changes were carried out to further improve the po...

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Detalles Bibliográficos
Autores principales: Nagle, Advait, Wu, Tao, Kuhen, Kelli, Gagaring, Kerstin, Borboa, Rachel, Francek, Caroline, Chen, Zhong, Plouffe, David, Lin, Xuena, Caldwell, Christopher, Ek, Jared, Skolnik, Suzanne, Liu, Fenghua, Wang, Jianling, Chang, Jonathan, Li, Chun, Liu, Bo, Hollenbeck, Thomas, Tuntland, Tove, Isbell, John, Chuan, Tiffany, Alper, Philip B., Fischli, Christoph, Brun, Reto, Lakshminarayana, Suresh B., Rottmann, Matthias, Diagana, Thierry T., Winzeler, Elizabeth A., Glynne, Richard, Tully, David C., Chatterjee, Arnab K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350218/
https://www.ncbi.nlm.nih.gov/pubmed/22524250
http://dx.doi.org/10.1021/jm300041e

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