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Neurosyphilis Presenting as Asymptomatic Optic Perineuritis
Introduction. Syphilis is a sexually transmitted disease that is known as “the great imitator” due to its wide variety of clinical presentations, including ocular disorders. There has been an increase in the rate of syphilis in the United States, especially in persons with HIV. We report a case of o...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350282/ https://www.ncbi.nlm.nih.gov/pubmed/22606498 http://dx.doi.org/10.1155/2012/621872 |
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author | Parker, Sarah E. Pula, John H. |
author_facet | Parker, Sarah E. Pula, John H. |
author_sort | Parker, Sarah E. |
collection | PubMed |
description | Introduction. Syphilis is a sexually transmitted disease that is known as “the great imitator” due to its wide variety of clinical presentations, including ocular disorders. There has been an increase in the rate of syphilis in the United States, especially in persons with HIV. We report a case of optic perineuritis in an asymptomatic male secondary to central nervous system (CNS) syphilis. Case Report. A 41-year-old man was found to have bilateral disc edema on a routine exam. Brain MRI was unremarkable, and lumbar puncture revealed a normal opening pressure, with an elevated cerebrospinal fluid white cell count. Orbit MRI showed optic nerve sheath expansion and enhancement, consistent with optic perineuritis. He tested positive for syphilis based on serum RPR and FTA-ABS. Conclusion. Ophthalmologic findings, including disc edema, may be the presenting features of CNS syphilis. Even in asymptomatic persons, perineuritis should be considered early, as diagnosis and treatment are imperative given the progressive nature of the disease. |
format | Online Article Text |
id | pubmed-3350282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33502822012-05-17 Neurosyphilis Presenting as Asymptomatic Optic Perineuritis Parker, Sarah E. Pula, John H. Case Rep Ophthalmol Med Case Report Introduction. Syphilis is a sexually transmitted disease that is known as “the great imitator” due to its wide variety of clinical presentations, including ocular disorders. There has been an increase in the rate of syphilis in the United States, especially in persons with HIV. We report a case of optic perineuritis in an asymptomatic male secondary to central nervous system (CNS) syphilis. Case Report. A 41-year-old man was found to have bilateral disc edema on a routine exam. Brain MRI was unremarkable, and lumbar puncture revealed a normal opening pressure, with an elevated cerebrospinal fluid white cell count. Orbit MRI showed optic nerve sheath expansion and enhancement, consistent with optic perineuritis. He tested positive for syphilis based on serum RPR and FTA-ABS. Conclusion. Ophthalmologic findings, including disc edema, may be the presenting features of CNS syphilis. Even in asymptomatic persons, perineuritis should be considered early, as diagnosis and treatment are imperative given the progressive nature of the disease. Hindawi Publishing Corporation 2012 2012-02-26 /pmc/articles/PMC3350282/ /pubmed/22606498 http://dx.doi.org/10.1155/2012/621872 Text en Copyright © 2012 S. E. Parker and J. H. Pula. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Parker, Sarah E. Pula, John H. Neurosyphilis Presenting as Asymptomatic Optic Perineuritis |
title | Neurosyphilis Presenting as Asymptomatic Optic Perineuritis |
title_full | Neurosyphilis Presenting as Asymptomatic Optic Perineuritis |
title_fullStr | Neurosyphilis Presenting as Asymptomatic Optic Perineuritis |
title_full_unstemmed | Neurosyphilis Presenting as Asymptomatic Optic Perineuritis |
title_short | Neurosyphilis Presenting as Asymptomatic Optic Perineuritis |
title_sort | neurosyphilis presenting as asymptomatic optic perineuritis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350282/ https://www.ncbi.nlm.nih.gov/pubmed/22606498 http://dx.doi.org/10.1155/2012/621872 |
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