Cargando…

Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury

BACKGROUND: The α(2)-adrenoreceptor agonist dexmedetomidine is known to provide neuroprotection under ischemic conditions. In this study we investigated whether dexmedetomidine has a protective effect in an in vitro model for traumatic brain injury. METHODS: Organotypic hippocampal slice cultures we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schoeler, Marc, Loetscher, Philip D, Rossaint, Rolf, Fahlenkamp, Astrid V, Eberhardt, Georg, Rex, Steffen, Weis, Joachim, Coburn, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350422/ https://www.ncbi.nlm.nih.gov/pubmed/22494498 http://dx.doi.org/10.1186/1471-2377-12-20

Ejemplares similares

Argon: Neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury
por: Loetscher, Philip D, et al.
Publicado: (2009)

Propofol: neuroprotection in an in vitro model of traumatic brain injury
por: Rossaint, Jan, et al.
Publicado: (2009)

Neuroprotective properties of levosimendan in an in vitro model of traumatic brain injury
por: Roehl, Anna B, et al.
Publicado: (2010)

Early cognitive function, recovery and well-being after sevoflurane and xenon anaesthesia in the elderly: a double-blinded randomized controlled trial
por: Cremer, Jan, et al.
Publicado: (2011)

Better haemodynamic stability under xenon anaesthesia than under isoflurane anaesthesia during partial nephrectomy – a secondary analysis of a randomised controlled trial
por: Schäfer, Patrick, et al.
Publicado: (2019)

Argon: Systematic Review on Neuro- and Organoprotective Properties of an “Inert” Gas
por: Höllig, Anke, et al.
Publicado: (2014)

Xenon consumption during general surgery: a retrospective observational study
por: Stoppe, Christian, et al.
Publicado: (2013)

Desflurane impairs outcome of organotypic hippocampal slices in an in vitro model of traumatic brain injury
por: Krings, Matthias, et al.
Publicado: (2016)

Neuroprotective effect of dexmedetomidine in a murine model of traumatic brain injury
por: Wu, Jin, et al.
Publicado: (2018)

Argon attenuates the emergence of secondary injury after traumatic brain injury within a 2-hour incubation period compared to desflurane: an in vitro study
por: Grüßer, Linda, et al.
Publicado: (2017)

Expression analysis following argon treatment in an in vivo model of transient middle cerebral artery occlusion in rats
por: Fahlenkamp, Astrid V, et al.
Publicado: (2014)

Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expression
por: Zhang, Man-He, et al.
Publicado: (2018)

The use of the Airtraq(® )optical laryngoscope for routine tracheal intubation in high-risk cardio-surgical patients
por: Schälte, Gereon, et al.
Publicado: (2011)

Solulin reduces infarct volume and regulates gene-expression in transient middle cerebral artery occlusion in rats
por: Ryang, Yu-Mi, et al.
Publicado: (2011)

Nausea and Vomiting following Balanced Xenon Anesthesia Compared to Sevoflurane: A Post-Hoc Explorative Analysis of a Randomized Controlled Trial
por: Fahlenkamp, Astrid V., et al.
Publicado: (2016)

Renal function following xenon anesthesia for partial nephrectomy—An explorative analysis of a randomized controlled study
por: Stevanovic, Ana, et al.
Publicado: (2017)

Laypersons can successfully place supraglottic airways with 3 minutes of training. A comparison of four different devices in the manikin
por: Schälte, Gereon, et al.
Publicado: (2011)

A 6-Step Approach to Gain Higher Quality Results From Organotypic Hippocampal Brain Slices in a Traumatic Brain Injury Model
por: Grüßer, Linda, et al.
Publicado: (2019)

Does a 4 diagram manual enable laypersons to operate the laryngeal mask supreme(®)? A pilot study in the manikin
por: Schälte, Gereon, et al.
Publicado: (2012)

The neuroprotective effect of dexmedetomidine and its mechanism
por: Hu, Yijun, et al.
Publicado: (2022)

Anesthesia, the developing brain, and dexmedetomidine for neuroprotection
por: Tsivitis, Alexandra, et al.
Publicado: (2023)

Subanesthetic xenon increases erythropoietin levels in humans and remains traceable in the first 24 hours after exposure: a randomized controlled trial
por: Ney, J, et al.
Publicado: (2015)

Blood Levels of Macrophage Migration Inhibitory Factor after Successful Resuscitation from Cardiac Arrest
por: Stoppe, Christian, et al.
Publicado: (2012)

Neuroprotective effects of dexmedetomidine against hyperoxia-induced injury in the developing rat brain
por: Endesfelder, Stefanie, et al.
Publicado: (2017)

Rethinking Neuroprotection in Severe Traumatic Brain Injury: Toward Bedside Neuroprotection
por: Zoerle, Tommaso, et al.
Publicado: (2017)

Update of the organoprotective properties of xenon and argon: from bench to beside
por: Anna, Roehl, et al.
Publicado: (2020)

Comparison of dexmedetomidine and propofol for sedation in patients with traumatic brain injury
por: Tarabrin, O, et al.
Publicado: (2014)

Dexmedetomidine attenuates traumatic brain injury: action pathway and mechanisms
por: Wang, Dong, et al.
Publicado: (2018)

Prolonged Mechanical Ventilation Alters the Expression Pattern of Angio-neogenetic Factors in a Pre-Clinical Rat Model
por: Bruells, Christian S., et al.
Publicado: (2013)

Effects of different fibrinogen concentrations on blood loss and coagulation parameters in a pig model of coagulopathy with blunt liver injury
por: Grottke, Oliver, et al.
Publicado: (2010)

Accuracy and precision of calibrated arterial pulse contour analysis in patients with subarachnoid hemorrhage requiring high-dose vasopressor therapy: a prospective observational clinical trial
por: Metzelder, Sebastian M, et al.
Publicado: (2014)

The Current Role of Dexmedetomidine as Neuroprotective Agent: An Updated Review
por: Liaquat, Zaara, et al.
Publicado: (2021)

The Importance of Intraoperative Selenium Blood Levels on Organ Dysfunction in Patients Undergoing Off-Pump Cardiac Surgery: A Randomised Controlled Trial
por: Stevanovic, Ana, et al.
Publicado: (2014)

Dexmedetomidine Protects Against Traumatic Brain Injury-Induced Acute Lung Injury in Mice
por: Wang, Yuanyuan, et al.
Publicado: (2018)

Neuroprotection by Estrogen and Progesterone in Traumatic Brain Injury and Spinal Cord Injury
por: Brotfain, Evgeni, et al.
Publicado: (2016)

Extended Coagulation Profiling in Isolated Traumatic Brain Injury: A CENTER-TBI Analysis
por: Böhm, Julia K., et al.
Publicado: (2021)

Neuroprotective effects of dexmedetomidine against isoflurane-induced neuronal injury via glutamate regulation in neonatal rats
por: Wang, Xue, et al.
Publicado: (2018)

Neuroprotective efficacy of magnesium sulphate in experimental traumatic brain injury
por: Erden, T, et al.
Publicado: (2002)

Neuroprotective effects of vagus nerve stimulation on traumatic brain injury
por: Zhou, Long, et al.
Publicado: (2014)

Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation
por: Kabadi, Shruti V., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_4daou4nb470gsjgo8ia5ai0vhn