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Cyclin D1 G870A Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Systematic Review of 22 Case-Control Studies

BACKGROUND: Cyclin D1 (CCND1) plays a vital role in cancer cell cycle progression. Numerous epidemiological studies have evaluated the association between the CCND1 G870A polymorphism and the risk of colorectal cancer. However, these studies have yielded conflicting results. To derive a more precise...

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Autores principales: Yang, Yongzhi, Wang, Feng, Shi, Chenzhang, Zou, Yang, Qin, Huanlong, Ma, Yanlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350479/
https://www.ncbi.nlm.nih.gov/pubmed/22606291
http://dx.doi.org/10.1371/journal.pone.0036813
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author Yang, Yongzhi
Wang, Feng
Shi, Chenzhang
Zou, Yang
Qin, Huanlong
Ma, Yanlei
author_facet Yang, Yongzhi
Wang, Feng
Shi, Chenzhang
Zou, Yang
Qin, Huanlong
Ma, Yanlei
author_sort Yang, Yongzhi
collection PubMed
description BACKGROUND: Cyclin D1 (CCND1) plays a vital role in cancer cell cycle progression. Numerous epidemiological studies have evaluated the association between the CCND1 G870A polymorphism and the risk of colorectal cancer. However, these studies have yielded conflicting results. To derive a more precise estimation of this association, we conducted a meta-analysis and systematic review. METHODOLOGY/PRINCIPAL FINDINGS: A comprehensive search was conducted to identify eligible studies of the CCND1 G870A polymorphism and colorectal cancer risk. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were derived from a fixed effect or random effect model. We applied a grading system (Venice criteria) that assessed the epidemiological strength of the association. A total of 22 publications that included 6157 cases and 8198 controls were identified. We found that the CCND1 G870A polymorphism was significantly associated with overall colorectal cancer risk (homozygote genetic model: OR = 1.130, 95% CI = 1.023–1.248, P = 0.016; heterozygote genetic model: OR = 1.124, 95% CI = 1.030–1.226, P = 0.009; dominant genetic model: OR = 1.127, 95% CI = 1.037–1.224, P = 0.005). After further stratified analyses, the increased risk was observed only in the subgroups of hospital-based studies, PCR-RFLP genotyping methods, sporadic colorectal cancer, and Caucasian ethnicity. CONCLUSIONS: The available evidence demonstrates that the CCND1 870A allele might be a low-penetrant risk factor for colorectal cancer.
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spelling pubmed-33504792012-05-17 Cyclin D1 G870A Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Systematic Review of 22 Case-Control Studies Yang, Yongzhi Wang, Feng Shi, Chenzhang Zou, Yang Qin, Huanlong Ma, Yanlei PLoS One Research Article BACKGROUND: Cyclin D1 (CCND1) plays a vital role in cancer cell cycle progression. Numerous epidemiological studies have evaluated the association between the CCND1 G870A polymorphism and the risk of colorectal cancer. However, these studies have yielded conflicting results. To derive a more precise estimation of this association, we conducted a meta-analysis and systematic review. METHODOLOGY/PRINCIPAL FINDINGS: A comprehensive search was conducted to identify eligible studies of the CCND1 G870A polymorphism and colorectal cancer risk. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were derived from a fixed effect or random effect model. We applied a grading system (Venice criteria) that assessed the epidemiological strength of the association. A total of 22 publications that included 6157 cases and 8198 controls were identified. We found that the CCND1 G870A polymorphism was significantly associated with overall colorectal cancer risk (homozygote genetic model: OR = 1.130, 95% CI = 1.023–1.248, P = 0.016; heterozygote genetic model: OR = 1.124, 95% CI = 1.030–1.226, P = 0.009; dominant genetic model: OR = 1.127, 95% CI = 1.037–1.224, P = 0.005). After further stratified analyses, the increased risk was observed only in the subgroups of hospital-based studies, PCR-RFLP genotyping methods, sporadic colorectal cancer, and Caucasian ethnicity. CONCLUSIONS: The available evidence demonstrates that the CCND1 870A allele might be a low-penetrant risk factor for colorectal cancer. Public Library of Science 2012-05-11 /pmc/articles/PMC3350479/ /pubmed/22606291 http://dx.doi.org/10.1371/journal.pone.0036813 Text en Yang et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yang, Yongzhi
Wang, Feng
Shi, Chenzhang
Zou, Yang
Qin, Huanlong
Ma, Yanlei
Cyclin D1 G870A Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Systematic Review of 22 Case-Control Studies
title Cyclin D1 G870A Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Systematic Review of 22 Case-Control Studies
title_full Cyclin D1 G870A Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Systematic Review of 22 Case-Control Studies
title_fullStr Cyclin D1 G870A Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Systematic Review of 22 Case-Control Studies
title_full_unstemmed Cyclin D1 G870A Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Systematic Review of 22 Case-Control Studies
title_short Cyclin D1 G870A Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Systematic Review of 22 Case-Control Studies
title_sort cyclin d1 g870a polymorphism contributes to colorectal cancer susceptibility: evidence from a systematic review of 22 case-control studies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350479/
https://www.ncbi.nlm.nih.gov/pubmed/22606291
http://dx.doi.org/10.1371/journal.pone.0036813
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