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Temporal Dissection of K-ras(G12D) Mutant In Vitro and In Vivo Using a Regulatable K-ras(G12D) Mouse Allele

Animal models which allow the temporal regulation of gene activities are valuable for dissecting gene function in tumorigenesis. Here we have constructed a conditional inducible estrogen receptor-K-ras(G12D) (ER-K-ras(G12D)) knock-in mice allele that allows us to temporally switch on or off the acti...

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Detalles Bibliográficos
Autores principales:	Wang, Zuoyun, Feng, Yan, Bardessy, Nabeel, Wong, Kwok-Kin, Liu, Xin-Yuan, Ji, Hongbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350485/ https://www.ncbi.nlm.nih.gov/pubmed/22606359 http://dx.doi.org/10.1371/journal.pone.0037308

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