Protein kinase C δ regulates the release of collagen type I from vascular smooth muscle cells via regulation of Cdc42

Collagen type I is the most abundant component of extracellular matrix in the arterial wall. Mice knocked out for the protein kinase C δ gene (PKCδ KO) show a marked reduction of collagen I in the arterial wall. The lack of PKCδ diminished the ability of arterial smooth muscle cells (SMCs) to secret...

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Detalles Bibliográficos
Autores principales: Lengfeld, Justin, Wang, Qiwei, Zohlman, Andrew, Salvarezza, Susana, Morgan, Stephanie, Ren, Jun, Kato, Kaori, Rodriguez-Boulan, Enrique, Liu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350558/
https://www.ncbi.nlm.nih.gov/pubmed/22456512
http://dx.doi.org/10.1091/mbc.E11-06-0531

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