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A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes

The respiratory metabolic cycle in budding yeast (Saccharomyces cerevisiae) consists of two phases that are most simply defined phenomenologically: low oxygen consumption (LOC) and high oxygen consumption (HOC). Each phase is associated with the periodic expression of thousands of genes, producing o...

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Autores principales: Slavov, Nikolai, Airoldi, Edoardo M., van Oudenaarden, Alexander, Botstein, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350561/
https://www.ncbi.nlm.nih.gov/pubmed/22456505
http://dx.doi.org/10.1091/mbc.E11-11-0961
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author Slavov, Nikolai
Airoldi, Edoardo M.
van Oudenaarden, Alexander
Botstein, David
author_facet Slavov, Nikolai
Airoldi, Edoardo M.
van Oudenaarden, Alexander
Botstein, David
author_sort Slavov, Nikolai
collection PubMed
description The respiratory metabolic cycle in budding yeast (Saccharomyces cerevisiae) consists of two phases that are most simply defined phenomenologically: low oxygen consumption (LOC) and high oxygen consumption (HOC). Each phase is associated with the periodic expression of thousands of genes, producing oscillating patterns of gene expression found in synchronized cultures and in single cells of slowly growing unsynchronized cultures. Systematic variation in the durations of the HOC and LOC phases can account quantitatively for well-studied transcriptional responses to growth rate differences. Here we show that a similar mechanism—transitions from the HOC phase to the LOC phase—can account for much of the common environmental stress response (ESR) and for the cross-protection by a preliminary heat stress (or slow growth rate) to subsequent lethal heat stress. Similar to the budding yeast metabolic cycle, we suggest that a metabolic cycle, coupled in a similar way to the ESR, in the distantly related fission yeast, Schizosaccharomyces pombe, and in humans can explain gene expression and respiratory patterns observed in these eukaryotes. Although metabolic cycling is associated with the G0/G1 phase of the cell division cycle of slowly growing budding yeast, transcriptional cycling was detected in the G2 phase of the division cycle in fission yeast, consistent with the idea that respiratory metabolic cycling occurs during the phases of the cell division cycle associated with mass accumulation in these divergent eukaryotes.
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spelling pubmed-33505612012-07-30 A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes Slavov, Nikolai Airoldi, Edoardo M. van Oudenaarden, Alexander Botstein, David Mol Biol Cell Articles The respiratory metabolic cycle in budding yeast (Saccharomyces cerevisiae) consists of two phases that are most simply defined phenomenologically: low oxygen consumption (LOC) and high oxygen consumption (HOC). Each phase is associated with the periodic expression of thousands of genes, producing oscillating patterns of gene expression found in synchronized cultures and in single cells of slowly growing unsynchronized cultures. Systematic variation in the durations of the HOC and LOC phases can account quantitatively for well-studied transcriptional responses to growth rate differences. Here we show that a similar mechanism—transitions from the HOC phase to the LOC phase—can account for much of the common environmental stress response (ESR) and for the cross-protection by a preliminary heat stress (or slow growth rate) to subsequent lethal heat stress. Similar to the budding yeast metabolic cycle, we suggest that a metabolic cycle, coupled in a similar way to the ESR, in the distantly related fission yeast, Schizosaccharomyces pombe, and in humans can explain gene expression and respiratory patterns observed in these eukaryotes. Although metabolic cycling is associated with the G0/G1 phase of the cell division cycle of slowly growing budding yeast, transcriptional cycling was detected in the G2 phase of the division cycle in fission yeast, consistent with the idea that respiratory metabolic cycling occurs during the phases of the cell division cycle associated with mass accumulation in these divergent eukaryotes. The American Society for Cell Biology 2012-05-15 /pmc/articles/PMC3350561/ /pubmed/22456505 http://dx.doi.org/10.1091/mbc.E11-11-0961 Text en © 2012 Slavov et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology.
spellingShingle Articles
Slavov, Nikolai
Airoldi, Edoardo M.
van Oudenaarden, Alexander
Botstein, David
A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes
title A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes
title_full A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes
title_fullStr A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes
title_full_unstemmed A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes
title_short A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes
title_sort conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350561/
https://www.ncbi.nlm.nih.gov/pubmed/22456505
http://dx.doi.org/10.1091/mbc.E11-11-0961
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