Aldosterone does not require angiotensin II to activate NCC through a WNK4–SPAK–dependent pathway

We and others have recently shown that angiotensin II can activate the sodium chloride cotransporter (NCC) through a WNK4–SPAK-dependent pathway. Because WNK4 was previously shown to be a negative regulator of NCC, it has been postulated that angiotensin II converts WNK4 to a positive regulator. Her...

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Detalles Bibliográficos
Autores principales: van der Lubbe, Nils, Lim, Christina H., Meima, Marcel E., van Veghel, Richard, Rosenbaek, Lena Lindtoft, Mutig, Kerim, Danser, Alexander H. J., Fenton, Robert A., Zietse, Robert, Hoorn, Ewout J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Signaling and Cell Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350624/
https://www.ncbi.nlm.nih.gov/pubmed/22549242
http://dx.doi.org/10.1007/s00424-012-1104-0

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