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Principles of mRNA transport in yeast
mRNA localization and localized translation is a common mechanism by which cellular asymmetry is achieved. In higher eukaryotes the mRNA transport machinery is required for such diverse processes as stem cell division and neuronal plasticity. Because mRNA localization in metazoans is highly complex,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SP Birkhäuser Verlag Basel
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350770/ https://www.ncbi.nlm.nih.gov/pubmed/22159587 http://dx.doi.org/10.1007/s00018-011-0902-4 |
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author | Heym, Roland Gerhard Niessing, Dierk |
author_facet | Heym, Roland Gerhard Niessing, Dierk |
author_sort | Heym, Roland Gerhard |
collection | PubMed |
description | mRNA localization and localized translation is a common mechanism by which cellular asymmetry is achieved. In higher eukaryotes the mRNA transport machinery is required for such diverse processes as stem cell division and neuronal plasticity. Because mRNA localization in metazoans is highly complex, studies at the molecular level have proven to be cumbersome. However, active mRNA transport has also been reported in fungi including Saccharomyces cerevisiae, Ustilago maydis and Candida albicans, in which these events are less difficult to study. Amongst them, budding yeast S. cerevisiae has yielded mechanistic insights that exceed our understanding of other mRNA localization events to date. In contrast to most reviews, we refrain here from summarizing mRNA localization events from different organisms. Instead we give an in-depth account of ASH1 mRNA localization in budding yeast. This approach is particularly suited to providing a more holistic view of the interconnection between the individual steps of mRNA localization, from transcriptional events to cytoplasmic mRNA transport and localized translation. Because of our advanced mechanistic understanding of mRNA localization in yeast, the present review may also be informative for scientists working, for example, on mRNA localization in embryogenesis or in neurons. |
format | Online Article Text |
id | pubmed-3350770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SP Birkhäuser Verlag Basel |
record_format | MEDLINE/PubMed |
spelling | pubmed-33507702012-05-30 Principles of mRNA transport in yeast Heym, Roland Gerhard Niessing, Dierk Cell Mol Life Sci Review mRNA localization and localized translation is a common mechanism by which cellular asymmetry is achieved. In higher eukaryotes the mRNA transport machinery is required for such diverse processes as stem cell division and neuronal plasticity. Because mRNA localization in metazoans is highly complex, studies at the molecular level have proven to be cumbersome. However, active mRNA transport has also been reported in fungi including Saccharomyces cerevisiae, Ustilago maydis and Candida albicans, in which these events are less difficult to study. Amongst them, budding yeast S. cerevisiae has yielded mechanistic insights that exceed our understanding of other mRNA localization events to date. In contrast to most reviews, we refrain here from summarizing mRNA localization events from different organisms. Instead we give an in-depth account of ASH1 mRNA localization in budding yeast. This approach is particularly suited to providing a more holistic view of the interconnection between the individual steps of mRNA localization, from transcriptional events to cytoplasmic mRNA transport and localized translation. Because of our advanced mechanistic understanding of mRNA localization in yeast, the present review may also be informative for scientists working, for example, on mRNA localization in embryogenesis or in neurons. SP Birkhäuser Verlag Basel 2011-12-13 2012 /pmc/articles/PMC3350770/ /pubmed/22159587 http://dx.doi.org/10.1007/s00018-011-0902-4 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Review Heym, Roland Gerhard Niessing, Dierk Principles of mRNA transport in yeast |
title | Principles of mRNA transport in yeast |
title_full | Principles of mRNA transport in yeast |
title_fullStr | Principles of mRNA transport in yeast |
title_full_unstemmed | Principles of mRNA transport in yeast |
title_short | Principles of mRNA transport in yeast |
title_sort | principles of mrna transport in yeast |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350770/ https://www.ncbi.nlm.nih.gov/pubmed/22159587 http://dx.doi.org/10.1007/s00018-011-0902-4 |
work_keys_str_mv | AT heymrolandgerhard principlesofmrnatransportinyeast AT niessingdierk principlesofmrnatransportinyeast |