Cargando…

Desferrioxamine Attenuates Doxorubicin-Induced Acute Cardiotoxicity through TFG-β/Smad p53 Pathway in Rat Model

Interaction of doxorubicin DOX with iron and the consequent generation of reactive oxygen species (ROS) is a major player in DOX-induced cardiomyopathy. Accordingly, this study has been initiated to investigate the preventive effect of the iron chelator, desferrioxamine (DFX), against DOX-induced ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Shabanah, Othman A., Aleisa, Abdulaziz M., Hafez, Mohamed M., Al-Rejaie, Salim S., Al-Yahya, Abdulaziz A., Bakheet, Saleh A., Al-Harbi, Mohamed M., Sayed-Ahmed, Mohamed M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350848/ https://www.ncbi.nlm.nih.gov/pubmed/22619697 http://dx.doi.org/10.1155/2012/619185

Ejemplares similares

Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling
por: Sayed-Ahmed, Mohamed M, et al.
Publicado: (2010)

Downregulation of Oxidative and Nitrosative Apoptotic Signaling by L-Carnitine in Ifosfamide-Induced Fanconi Syndrome Rat Model
por: Sayed-Ahmed, Mohamed M., et al.
Publicado: (2012)

Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat
por: Al-Rejaie, Salem S, et al.
Publicado: (2013)

Association between Paraoxonases Gene Expression and Oxidative Stress in Hepatotoxicity Induced by CCl(4)
por: Hafez, Mohamed M., et al.
Publicado: (2014)

Metallothionein induction reduces caspase-3 activity and TNFα levels with preservation of cognitive function and intact hippocampal neurons in carmustine-treated rats
por: Helal, Gouda K, et al.
Publicado: (2009)

Doxorubicin Toxicity can be Ameliorated during Antioxidant L-Carnitine Supplementation
por: Alshabanah, Othman A., et al.
Publicado: (2010)

Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine
por: Abd-Allah, Adel RA, et al.
Publicado: (2009)

Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl(4)-induced hepatotoxicity in rats
por: Hafez, Mohamed M., et al.
Publicado: (2015)

Effect of ginseng extract on the TGF-β1 signaling pathway in CCl(4)-induced liver fibrosis in rats
por: Hafez, Mohamed M., et al.
Publicado: (2017)

Human papillomavirus genotyping and integration in ovarian cancer Saudi patients
por: Al-Shabanah, Othman A, et al.
Publicado: (2013)

Inhibitory Effect of Ginseng on Breast Cancer Cell Line Growth Via Up-Regulation of Cyclin Dependent Kinase Inhibitor, p21 and p53
por: AL Shabanah, Othman A, et al.
Publicado: (2016)

Inhibition of Gene Expression of Organic Cation/Carnitine Transporter and Antioxidant Enzymes in Oxazaphosphorines-Induced Acute Cardiomyopathic Rat Models
por: Sayed-Ahmed, Mohamed M., et al.
Publicado: (2012)

Neuro-protective effect of rutin against Cisplatin-induced neurotoxic rat model
por: Almutairi, Mashal M., et al.
Publicado: (2017)

Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats
por: Alhoshani, Ali R., et al.
Publicado: (2017)

Characterization of Apoptosis in a Breast Cancer Cell Line after IL-10 Silencing
por: Alotaibi, Moureq R, et al.
Publicado: (2018)

Gender difference following high cholesterol diet induced renal injury and the protective role of rutin and ascorbic acid combination in Wistar albino rats
por: Al-Rejaie, Salim Salih, et al.
Publicado: (2012)

Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells
por: Abdullah, Mashan L., et al.
Publicado: (2018)

Telmisartan inhibits hyperalgesia and inflammatory progression in a diabetic neuropathic pain model of Wistar rats
por: Al-Rejaie, Salim S., et al.
Publicado: (2015)

Carnitine Supplementation Attenuates Sunitinib-Induced Inhibition of AMP-Activated Protein Kinase Downstream Signals in Cardiac Tissues
por: Sayed-Ahmed, Mohamed M., et al.
Publicado: (2019)

Pretreatment of Gymnema sylvestre revealed the protection against acetic acid-induced ulcerative colitis in rats
por: Aleisa, Abdulaziz M, et al.
Publicado: (2014)

Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition
por: Abdullah, Mashan L., et al.
Publicado: (2021)

Rutin Attenuates Hepatotoxicity in High-Cholesterol-Diet-Fed Rats
por: AlSharari, Shakir D., et al.
Publicado: (2016)

Correction: Utility of Dexrazoxane for the Attenuation of Epirubicin-Induced Genetic Alterations in Mouse Germ Cells
por: Attia, Sabry M., et al.
Publicado: (2016)

Utility of Dexrazoxane for the Attenuation of Epirubicin-Induced Genetic Alterations in Mouse Germ Cells
por: Attia, Sabry M., et al.
Publicado: (2016)

Renin angiotensin system blockage by losartan neutralize hypercholesterolemia-induced inflammatory and oxidative injuries
por: AlSaad, Abdulaziz M.S., et al.
Publicado: (2020)

Baicalein Neutralizes Hypercholesterolemia-Induced Aggravation of Oxidative Injury in Rats
por: AlSaad, Abdulaziz MS, et al.
Publicado: (2020)

Acacia senegal gum exudate offers protection against cyclophosphamide-induced urinary bladder cytotoxicity
por: Al-Yahya, Abdulaziz A, et al.
Publicado: (2009)

Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice
por: Wang, Xinkun, et al.
Publicado: (2014)

Concomitant Sub-Chronic Administration of Small-Size Gold Nanoparticles Aggravates Doxorubicin-Induced Liver Oxidative and Inflammatory Damage, Hyperlipidemia, and Hepatic Steatosis
por: Alshammari, Ghedeir M., et al.
Publicado: (2023)

Dendrimer-doxorubicin conjugates exhibit improved anticancer activity and reduce doxorubicin-induced cardiotoxicity in a murine hepatocellular carcinoma model
por: Kuruvilla, Sibu P., et al.
Publicado: (2017)

The role of ivabradine in doxorubicin-induced cardiotoxicity: exploring of underlying argument
por: Al-kuraishy, Hayder M., et al.
Publicado: (2022)

Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease
por: Mohany, Mohamed, et al.
Publicado: (2021)

The Role of NF-κB and Bax/Bcl-2/Caspase-3 Signaling Pathways in the Protective Effects of Sacubitril/Valsartan (Entresto) against HFD/STZ-Induced Diabetic Kidney Disease
por: Mohany, Mohamed, et al.
Publicado: (2022)

A novel variant of RBCK1 gene causes mild polyglucosan myopathy
por: AlAnzi, Talal, et al.
Publicado: (2022)

Protective effect of cafestol against doxorubicin-induced cardiotoxicity in rats by activating the Nrf2 pathway
por: Al-Kenany, Sara A., et al.
Publicado: (2023)

Protective effect of nebivolol on doxorubicin-induced cardiotoxicity in rats
por: Mohamed, Enas Ahmed, et al.
Publicado: (2018)

Pristimerin protects against doxorubicin-induced cardiotoxicity and fibrosis through modulation of Nrf2 and MAPK/NF-kB signaling pathways
por: El-Agamy, Dina S, et al.
Publicado: (2018)

Evidence that the Tfg1/Tfg2 dimer interface of TFIIF lies near the active center of the RNA polymerase II initiation complex
por: Freire-Picos, M. Angeles, et al.
Publicado: (2005)

Effects of Thymoquinone Alone or in Combination with Losartan on the Cardiotoxicity Caused by Oxidative Stress and Inflammation in Hypercholesterolemia
por: Al-Oanzi, Ziad H., et al.
Publicado: (2022)

Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals
por: Al-malky, Hamdan S., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_f7l4h91qahepbblejkuotagot2