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Retinoblastoma in the Democratic Republic of Congo: 20-Year Review from a Tertiary Hospital in Kinshasa
Background. To determine clinical profile and management of retinoblastoma among children at Kinshasa in Democratic Republic of Congo. Patients and methods. The medical records of patients with a diagnosis of retinoblastoma seen at the University Hospital of Kinshasa from January 1985 till December...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350961/ https://www.ncbi.nlm.nih.gov/pubmed/22619679 http://dx.doi.org/10.1155/2012/920468 |
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author | Kazadi Lukusa, Aimé Aloni, Michel Ntetani Kadima-Tshimanga, Bertin Mvitu-Muaka, Moïse Gini Ehungu, Jean Lambert Ngiyulu, René Ekulu Mfutu, Pépé Budiongo Nzazi, Aléine |
author_facet | Kazadi Lukusa, Aimé Aloni, Michel Ntetani Kadima-Tshimanga, Bertin Mvitu-Muaka, Moïse Gini Ehungu, Jean Lambert Ngiyulu, René Ekulu Mfutu, Pépé Budiongo Nzazi, Aléine |
author_sort | Kazadi Lukusa, Aimé |
collection | PubMed |
description | Background. To determine clinical profile and management of retinoblastoma among children at Kinshasa in Democratic Republic of Congo. Patients and methods. The medical records of patients with a diagnosis of retinoblastoma seen at the University Hospital of Kinshasa from January 1985 till December 2005 were retrospectively reviewed. Demographic profile, clinical data, modes of treatment and outcome were analysed. Results. A total of 49 children, of whom 40 had adequate data on record were identified as retinoblastoma (28 males and 12 females). Nine cases had bilateral disease. The median age at the first symptoms was 9 months (range, 1 month to 6 years) for unilateral retinoblastoma and 18 months (range, 1 month to 3.5 years) for bilateral retinoblastoma. The median age at the first oncology consultation was 2.4 years (range, 6 months to 6 years) for unilateral retinoblastoma and 2.4years (range, 9 months to 4 years) for bilateral disease. Leukokoria was present in 67.5% of subjects. Seventy-five percent abandoned the treatment. The mortality was 92.5%. Conclusion. In Democratic Republic of Congo, retinoblastoma remains a life threatening disease characterized by late referral to a specialized unit and affordability of chemotherapy; all leading to an extension of the disease and high mortality. |
format | Online Article Text |
id | pubmed-3350961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33509612012-05-22 Retinoblastoma in the Democratic Republic of Congo: 20-Year Review from a Tertiary Hospital in Kinshasa Kazadi Lukusa, Aimé Aloni, Michel Ntetani Kadima-Tshimanga, Bertin Mvitu-Muaka, Moïse Gini Ehungu, Jean Lambert Ngiyulu, René Ekulu Mfutu, Pépé Budiongo Nzazi, Aléine J Cancer Epidemiol Clinical Study Background. To determine clinical profile and management of retinoblastoma among children at Kinshasa in Democratic Republic of Congo. Patients and methods. The medical records of patients with a diagnosis of retinoblastoma seen at the University Hospital of Kinshasa from January 1985 till December 2005 were retrospectively reviewed. Demographic profile, clinical data, modes of treatment and outcome were analysed. Results. A total of 49 children, of whom 40 had adequate data on record were identified as retinoblastoma (28 males and 12 females). Nine cases had bilateral disease. The median age at the first symptoms was 9 months (range, 1 month to 6 years) for unilateral retinoblastoma and 18 months (range, 1 month to 3.5 years) for bilateral retinoblastoma. The median age at the first oncology consultation was 2.4 years (range, 6 months to 6 years) for unilateral retinoblastoma and 2.4years (range, 9 months to 4 years) for bilateral disease. Leukokoria was present in 67.5% of subjects. Seventy-five percent abandoned the treatment. The mortality was 92.5%. Conclusion. In Democratic Republic of Congo, retinoblastoma remains a life threatening disease characterized by late referral to a specialized unit and affordability of chemotherapy; all leading to an extension of the disease and high mortality. Hindawi Publishing Corporation 2012 2012-04-26 /pmc/articles/PMC3350961/ /pubmed/22619679 http://dx.doi.org/10.1155/2012/920468 Text en Copyright © 2012 Aimé Kazadi Lukusa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Kazadi Lukusa, Aimé Aloni, Michel Ntetani Kadima-Tshimanga, Bertin Mvitu-Muaka, Moïse Gini Ehungu, Jean Lambert Ngiyulu, René Ekulu Mfutu, Pépé Budiongo Nzazi, Aléine Retinoblastoma in the Democratic Republic of Congo: 20-Year Review from a Tertiary Hospital in Kinshasa |
title | Retinoblastoma in the Democratic Republic of Congo: 20-Year Review from a Tertiary Hospital in Kinshasa |
title_full | Retinoblastoma in the Democratic Republic of Congo: 20-Year Review from a Tertiary Hospital in Kinshasa |
title_fullStr | Retinoblastoma in the Democratic Republic of Congo: 20-Year Review from a Tertiary Hospital in Kinshasa |
title_full_unstemmed | Retinoblastoma in the Democratic Republic of Congo: 20-Year Review from a Tertiary Hospital in Kinshasa |
title_short | Retinoblastoma in the Democratic Republic of Congo: 20-Year Review from a Tertiary Hospital in Kinshasa |
title_sort | retinoblastoma in the democratic republic of congo: 20-year review from a tertiary hospital in kinshasa |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350961/ https://www.ncbi.nlm.nih.gov/pubmed/22619679 http://dx.doi.org/10.1155/2012/920468 |
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