Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy

Islet cell transplantation offers a potential cure for type 1 diabetes, but it is challenged by insufficient donor tissue and side effects of current immunosuppressive drugs. Therefore, alternative sources of insulin-producing cells and isletfriendly immunosuppression are required to increase the ef...

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Detalles Bibliográficos
Autores principales: Wang, Xiaojie, Metzger, Daniel L., Meloche, Mark, Hao, Jianqiang, Ao, Ziliang, Warnock, Garth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350967/
https://www.ncbi.nlm.nih.gov/pubmed/22611393
http://dx.doi.org/10.1155/2012/414812
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author Wang, Xiaojie
Metzger, Daniel L.
Meloche, Mark
Hao, Jianqiang
Ao, Ziliang
Warnock, Garth L.
author_facet Wang, Xiaojie
Metzger, Daniel L.
Meloche, Mark
Hao, Jianqiang
Ao, Ziliang
Warnock, Garth L.
author_sort Wang, Xiaojie
collection PubMed
description Islet cell transplantation offers a potential cure for type 1 diabetes, but it is challenged by insufficient donor tissue and side effects of current immunosuppressive drugs. Therefore, alternative sources of insulin-producing cells and isletfriendly immunosuppression are required to increase the efficiency and safety of this procedure. Beta cells can be transdifferentiated from precursors or another heterologous (non-beta-cell) source. Recent advances in beta cell regeneration from somatic cells such as fibroblasts could circumvent the usage of immunosuppressive drugs. Therefore, generation of patient-specific beta cells provides the potential of an evolutionary treatment for patients with diabetes.
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spelling pubmed-33509672012-05-18 Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy Wang, Xiaojie Metzger, Daniel L. Meloche, Mark Hao, Jianqiang Ao, Ziliang Warnock, Garth L. Int J Endocrinol Review Article Islet cell transplantation offers a potential cure for type 1 diabetes, but it is challenged by insufficient donor tissue and side effects of current immunosuppressive drugs. Therefore, alternative sources of insulin-producing cells and isletfriendly immunosuppression are required to increase the efficiency and safety of this procedure. Beta cells can be transdifferentiated from precursors or another heterologous (non-beta-cell) source. Recent advances in beta cell regeneration from somatic cells such as fibroblasts could circumvent the usage of immunosuppressive drugs. Therefore, generation of patient-specific beta cells provides the potential of an evolutionary treatment for patients with diabetes. Hindawi Publishing Corporation 2012 2012-04-26 /pmc/articles/PMC3350967/ /pubmed/22611393 http://dx.doi.org/10.1155/2012/414812 Text en Copyright © 2012 Xiaojie Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Xiaojie
Metzger, Daniel L.
Meloche, Mark
Hao, Jianqiang
Ao, Ziliang
Warnock, Garth L.
Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy
title Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy
title_full Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy
title_fullStr Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy
title_full_unstemmed Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy
title_short Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy
title_sort generation of transplantable beta cells for patient-specific cell therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350967/
https://www.ncbi.nlm.nih.gov/pubmed/22611393
http://dx.doi.org/10.1155/2012/414812
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