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The Bad, the Good, and the Ugly about Oxidative Stress
Alzheimer's disease (AD), Parkinson's disease (PD), and cancer (e.g., leukemia) are the most devastating disorders affecting millions of people worldwide. Except for some kind of cancers, no effective and/or definitive therapeutic treatment aimed to reduce or to retard the clinic and patho...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350994/ https://www.ncbi.nlm.nih.gov/pubmed/22619696 http://dx.doi.org/10.1155/2012/163913 |
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author | Jimenez-Del-Rio, Marlene Velez-Pardo, Carlos |
author_facet | Jimenez-Del-Rio, Marlene Velez-Pardo, Carlos |
author_sort | Jimenez-Del-Rio, Marlene |
collection | PubMed |
description | Alzheimer's disease (AD), Parkinson's disease (PD), and cancer (e.g., leukemia) are the most devastating disorders affecting millions of people worldwide. Except for some kind of cancers, no effective and/or definitive therapeutic treatment aimed to reduce or to retard the clinic and pathologic symptoms induced by AD and PD is presently available. Therefore, it is urgently needed to understand the molecular basis of these disorders. Since oxidative stress (OS) is an important etiologic factor of the pathologic process of AD, PD, and cancer, understanding how intracellular signaling pathways respond to OS will have a significant implication in the therapy of these diseases. Here, we propose a model of minimal completeness of cell death signaling induced by OS as a mechanistic explanation of neuronal and cancer cell demise. This mechanism might provide the basis for therapeutic design strategies. Finally, we will attempt to associate PD, cancer, and OS. This paper critically analyzes the evidence that support the “oxidative stress model” in neurodegeneration and cancer. |
format | Online Article Text |
id | pubmed-3350994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33509942012-05-22 The Bad, the Good, and the Ugly about Oxidative Stress Jimenez-Del-Rio, Marlene Velez-Pardo, Carlos Oxid Med Cell Longev Review Article Alzheimer's disease (AD), Parkinson's disease (PD), and cancer (e.g., leukemia) are the most devastating disorders affecting millions of people worldwide. Except for some kind of cancers, no effective and/or definitive therapeutic treatment aimed to reduce or to retard the clinic and pathologic symptoms induced by AD and PD is presently available. Therefore, it is urgently needed to understand the molecular basis of these disorders. Since oxidative stress (OS) is an important etiologic factor of the pathologic process of AD, PD, and cancer, understanding how intracellular signaling pathways respond to OS will have a significant implication in the therapy of these diseases. Here, we propose a model of minimal completeness of cell death signaling induced by OS as a mechanistic explanation of neuronal and cancer cell demise. This mechanism might provide the basis for therapeutic design strategies. Finally, we will attempt to associate PD, cancer, and OS. This paper critically analyzes the evidence that support the “oxidative stress model” in neurodegeneration and cancer. Hindawi Publishing Corporation 2012 2012-04-26 /pmc/articles/PMC3350994/ /pubmed/22619696 http://dx.doi.org/10.1155/2012/163913 Text en Copyright © 2012 M. Jimenez-Del-Rio and C. Velez-Pardo. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Jimenez-Del-Rio, Marlene Velez-Pardo, Carlos The Bad, the Good, and the Ugly about Oxidative Stress |
title | The Bad, the Good, and the Ugly about Oxidative Stress |
title_full | The Bad, the Good, and the Ugly about Oxidative Stress |
title_fullStr | The Bad, the Good, and the Ugly about Oxidative Stress |
title_full_unstemmed | The Bad, the Good, and the Ugly about Oxidative Stress |
title_short | The Bad, the Good, and the Ugly about Oxidative Stress |
title_sort | bad, the good, and the ugly about oxidative stress |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350994/ https://www.ncbi.nlm.nih.gov/pubmed/22619696 http://dx.doi.org/10.1155/2012/163913 |
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