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Temporal Requirements of cMyc Protein for Reprogramming Mouse Fibroblasts

Exogenous expression of Oct4, Sox2, Klf4, and cMyc forces mammalian somatic cells to adopt molecular and phenotypic characteristics of embryonic stem cells, commencing with the required suppression of lineage-associated genes (e.g., Thy1 in mouse). Although omitting cMyc from the reprogramming cockt...

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Detalles Bibliográficos
Autores principales:	Heffernan, Corey, Sumer, Huseyin, Malaver-Ortega, Luis F., Verma, Paul J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350996/ https://www.ncbi.nlm.nih.gov/pubmed/22619682 http://dx.doi.org/10.1155/2012/541014

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