Cargando…
Seven naphtho-γ-pyrones from the marine-derived fungus Alternaria alternata: structure elucidation and biological properties
Eight bioactive pyrone derivatives were identified from the culture of Alternaria alternata strain D2006, isolated from the marine soft coral Denderonephthya hemprichi, which was selected as its profound antimicrobial activities. The compounds were assigned as pyrophen (1), rubrofusarin B (2), fonse...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350997/ https://www.ncbi.nlm.nih.gov/pubmed/22377027 http://dx.doi.org/10.1186/2191-2858-2-6 |
_version_ | 1782232724545732608 |
---|---|
author | Shaaban, Mohamed Shaaban, Khaled A Abdel-Aziz, Mohamed S |
author_facet | Shaaban, Mohamed Shaaban, Khaled A Abdel-Aziz, Mohamed S |
author_sort | Shaaban, Mohamed |
collection | PubMed |
description | Eight bioactive pyrone derivatives were identified from the culture of Alternaria alternata strain D2006, isolated from the marine soft coral Denderonephthya hemprichi, which was selected as its profound antimicrobial activities. The compounds were assigned as pyrophen (1), rubrofusarin B (2), fonsecin (3), and fonsecin B (5) beside to the four dimeric naphtho-γ-pyrones; aurasperone A (6), aurasperone B (7), aurasperone C (8), and aurasperone F (9). Structures of the isolated compounds were identified on the basis of 1D and 2D NMR spectroscopy and mass (EI, ESI, HRESI) data, and by comparison with the literature. Configuration of the four dimeric naphtho-γ-pyrones 6-9 was analyzed by CD spectra, exhibiting an identical stereochemistry. |
format | Online Article Text |
id | pubmed-3350997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-33509972012-05-14 Seven naphtho-γ-pyrones from the marine-derived fungus Alternaria alternata: structure elucidation and biological properties Shaaban, Mohamed Shaaban, Khaled A Abdel-Aziz, Mohamed S Org Med Chem Lett Original Article Eight bioactive pyrone derivatives were identified from the culture of Alternaria alternata strain D2006, isolated from the marine soft coral Denderonephthya hemprichi, which was selected as its profound antimicrobial activities. The compounds were assigned as pyrophen (1), rubrofusarin B (2), fonsecin (3), and fonsecin B (5) beside to the four dimeric naphtho-γ-pyrones; aurasperone A (6), aurasperone B (7), aurasperone C (8), and aurasperone F (9). Structures of the isolated compounds were identified on the basis of 1D and 2D NMR spectroscopy and mass (EI, ESI, HRESI) data, and by comparison with the literature. Configuration of the four dimeric naphtho-γ-pyrones 6-9 was analyzed by CD spectra, exhibiting an identical stereochemistry. Springer 2012-02-29 /pmc/articles/PMC3350997/ /pubmed/22377027 http://dx.doi.org/10.1186/2191-2858-2-6 Text en Copyright ©2012 Shaaban et al; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Shaaban, Mohamed Shaaban, Khaled A Abdel-Aziz, Mohamed S Seven naphtho-γ-pyrones from the marine-derived fungus Alternaria alternata: structure elucidation and biological properties |
title | Seven naphtho-γ-pyrones from the marine-derived fungus Alternaria alternata: structure elucidation and biological properties |
title_full | Seven naphtho-γ-pyrones from the marine-derived fungus Alternaria alternata: structure elucidation and biological properties |
title_fullStr | Seven naphtho-γ-pyrones from the marine-derived fungus Alternaria alternata: structure elucidation and biological properties |
title_full_unstemmed | Seven naphtho-γ-pyrones from the marine-derived fungus Alternaria alternata: structure elucidation and biological properties |
title_short | Seven naphtho-γ-pyrones from the marine-derived fungus Alternaria alternata: structure elucidation and biological properties |
title_sort | seven naphtho-γ-pyrones from the marine-derived fungus alternaria alternata: structure elucidation and biological properties |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350997/ https://www.ncbi.nlm.nih.gov/pubmed/22377027 http://dx.doi.org/10.1186/2191-2858-2-6 |
work_keys_str_mv | AT shaabanmohamed sevennaphthogpyronesfromthemarinederivedfungusalternariaalternatastructureelucidationandbiologicalproperties AT shaabankhaleda sevennaphthogpyronesfromthemarinederivedfungusalternariaalternatastructureelucidationandbiologicalproperties AT abdelazizmohameds sevennaphthogpyronesfromthemarinederivedfungusalternariaalternatastructureelucidationandbiologicalproperties |