Ectopic over-expression of tristetraprolin in human cancer cells promotes biogenesis of let-7 by down-regulation of Lin28

Tristetraprolin (TTP) is a AU-rich element (ARE) binding protein and exhibits suppressive effects on cell growth through down-regulation of ARE-containing oncogenes. The let-7 microRNA has emerged as a significant factor in tumor suppression. Both TTP and let-7 are often repressed in human cancers,...

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Detalles Bibliográficos
Autores principales: Kim, Chae Won, Vo, Mai-Tram, Kim, Hong Kyeung, Lee, Hyun Hee, Yoon, Nal Ae, Lee, Byung Ju, Min, Young Joo, Joo, Won Duk, Cha, Hee Jeong, Park, Jeong Woo, Cho, Wha Ja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351177/
https://www.ncbi.nlm.nih.gov/pubmed/22210895
http://dx.doi.org/10.1093/nar/gkr1302

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