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Crystal structure of human polynucleotide phosphorylase: insights into its domain function in RNA binding and degradation

Human polynucleotide phosphorylase (hPNPase) is a 3′-to-5′ exoribonuclease that degrades specific mRNA and miRNA, and imports RNA into mitochondria, and thus regulates diverse physiological processes, including cellular senescence and homeostasis. However, the RNA-processing mechanism by hPNPase, pa...

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Detalles Bibliográficos
Autores principales:	Lin, Chia Liang, Wang, Yi-Ting, Yang, Wei-Zen, Hsiao, Yu-Yuan, Yuan, Hanna S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351181/ https://www.ncbi.nlm.nih.gov/pubmed/22210891 http://dx.doi.org/10.1093/nar/gkr1281

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