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The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases

In mammals, the SET1 family of lysine methyltransferases (KMTs), which includes MLL1-5, SET1A and SET1B, catalyzes the methylation of lysine-4 (Lys-4) on histone H3. Recent reports have demonstrated that a three-subunit complex composed of WD-repeat protein-5 (WDR5), retinoblastoma-binding protein-5...

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Detalles Bibliográficos
Autores principales:	Zhang, Pamela, Lee, Hwabin, Brunzelle, Joseph S., Couture, Jean-Francois
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351189/ https://www.ncbi.nlm.nih.gov/pubmed/22266653 http://dx.doi.org/10.1093/nar/gkr1235

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