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Glucose-Dependent Regulation of NR2F2 Promoter and Influence of SNP-rs3743462 on Whole Body Insulin Sensitivity

BACKGROUND: The Nuclear Receptor 2F2 (NR2F2/COUP-TFII) heterozygous knockout mice display low basal insulinemia and enhanced insulin sensitivity. We previously established that insulin represses NR2F2 gene expression in pancreatic β-cells. The cis-regulatory region of the NR2F2 promoter is unknown a...

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Detalles Bibliográficos
Autores principales:	Boutant, Marie, Ramos, Oscar Henrique Pereira, Lecoeur, Cécile, Vaillant, Emmanuel, Philippe, Julien, Zhang, Pili, Perilhou, Anaïs, Valcarcel, Beatriz, Sebert, Sylvain, Jarvelin, Mario-Ritta, Balkau, Beverley, Scott, Donald, Froguel, Philippe, Vaxillaire, Martine, Vasseur-Cognet, Mireille
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351448/ https://www.ncbi.nlm.nih.gov/pubmed/22606236 http://dx.doi.org/10.1371/journal.pone.0035810

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