A Novel High-Throughput Assay for Islet Respiration Reveals Uncoupling of Rodent and Human Islets

BACKGROUND: The pancreatic beta cell is unique in its response to nutrient by increased fuel oxidation. Recent studies have demonstrated that oxygen consumption rate (OCR) may be a valuable predictor of islet quality and long term nutrient responsiveness. To date, high-throughput and user-friendly a...

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Detalles Bibliográficos
Autores principales: Wikstrom, Jakob D., Sereda, Samuel B., Stiles, Linsey, Elorza, Alvaro, Allister, Emma M., Neilson, Andy, Ferrick, David A., Wheeler, Michael B., Shirihai, Orian S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351473/
https://www.ncbi.nlm.nih.gov/pubmed/22606219
http://dx.doi.org/10.1371/journal.pone.0033023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351473/
https://www.ncbi.nlm.nih.gov/pubmed/22606219
http://dx.doi.org/10.1371/journal.pone.0033023

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