A convenient route to optically pure α-alkyl-β-(sec-amino)alanines

The cyclization of N-Boc-α-alkylserines to corresponding β-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced N-Boc-α-alkyl-β-(sec-amino)alanines. The removal of the Boc group gives di-hydrochlo...

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Detalles Bibliográficos
Autores principales: Olma, A., Lasota, A., Kudaj, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351611/
https://www.ncbi.nlm.nih.gov/pubmed/21847610
http://dx.doi.org/10.1007/s00726-011-1055-3
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author Olma, A.
Lasota, A.
Kudaj, A.
author_facet Olma, A.
Lasota, A.
Kudaj, A.
author_sort Olma, A.
collection PubMed
description The cyclization of N-Boc-α-alkylserines to corresponding β-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced N-Boc-α-alkyl-β-(sec-amino)alanines. The removal of the Boc group gives di-hydrochlorides of non-protein amino acids. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00726-011-1055-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-33516112012-05-31 A convenient route to optically pure α-alkyl-β-(sec-amino)alanines Olma, A. Lasota, A. Kudaj, A. Amino Acids Short Communication The cyclization of N-Boc-α-alkylserines to corresponding β-lactones under Mitsunobu reaction conditions and the ring opening with heterocyclic amines (pyrrolidine, piperidine, morpholine and thiomorpholine) produced N-Boc-α-alkyl-β-(sec-amino)alanines. The removal of the Boc group gives di-hydrochlorides of non-protein amino acids. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00726-011-1055-3) contains supplementary material, which is available to authorized users. Springer Vienna 2011-08-17 2012 /pmc/articles/PMC3351611/ /pubmed/21847610 http://dx.doi.org/10.1007/s00726-011-1055-3 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Short Communication
Olma, A.
Lasota, A.
Kudaj, A.
A convenient route to optically pure α-alkyl-β-(sec-amino)alanines
title A convenient route to optically pure α-alkyl-β-(sec-amino)alanines
title_full A convenient route to optically pure α-alkyl-β-(sec-amino)alanines
title_fullStr A convenient route to optically pure α-alkyl-β-(sec-amino)alanines
title_full_unstemmed A convenient route to optically pure α-alkyl-β-(sec-amino)alanines
title_short A convenient route to optically pure α-alkyl-β-(sec-amino)alanines
title_sort convenient route to optically pure α-alkyl-β-(sec-amino)alanines
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351611/
https://www.ncbi.nlm.nih.gov/pubmed/21847610
http://dx.doi.org/10.1007/s00726-011-1055-3
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