Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects

BACKGROUND: Disassembly of the viral capsid following penetration into the cytoplasm, or uncoating, is a poorly understood stage of retrovirus infection. Based on previous studies of HIV-1 CA mutants exhibiting altered capsid stability, we concluded that formation of a capsid of optimal intrinsic st...

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Detalles Bibliográficos
Autores principales: Yang, Ruifeng, Shi, Jiong, Byeon, In-Ja L, Ahn, Jinwoo, Sheehan, Jonathan H, Meiler, Jens, Gronenborn, Angela M, Aiken, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351742/
https://www.ncbi.nlm.nih.gov/pubmed/22515365
http://dx.doi.org/10.1186/1742-4690-9-30

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